O2T10_HUMAN
ID O2T10_HUMAN Reviewed; 312 AA.
AC Q8NGZ9; B2RNK7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 2T10;
DE AltName: Full=Olfactory receptor OR1-64;
GN Name=OR2T10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T10";
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DR EMBL; AB065616; BAC05843.1; -; Genomic_DNA.
DR EMBL; CH471257; EAW57528.1; -; Genomic_DNA.
DR EMBL; BC136937; AAI36938.1; -; mRNA.
DR EMBL; BC136940; AAI36941.1; -; mRNA.
DR EMBL; BK004478; DAA04876.1; -; Genomic_DNA.
DR CCDS; CCDS31121.1; -.
DR RefSeq; NP_001004693.1; NM_001004693.1.
DR RefSeq; XP_016855762.1; XM_017000273.1.
DR AlphaFoldDB; Q8NGZ9; -.
DR SMR; Q8NGZ9; -.
DR BioGRID; 126037; 3.
DR STRING; 9606.ENSP00000329210; -.
DR GlyGen; Q8NGZ9; 1 site.
DR iPTMnet; Q8NGZ9; -.
DR PhosphoSitePlus; Q8NGZ9; -.
DR BioMuta; OR2T10; -.
DR DMDM; 74762586; -.
DR MassIVE; Q8NGZ9; -.
DR PaxDb; Q8NGZ9; -.
DR PRIDE; Q8NGZ9; -.
DR Antibodypedia; 57446; 41 antibodies from 18 providers.
DR DNASU; 127069; -.
DR Ensembl; ENST00000330500.4; ENSP00000329210.2; ENSG00000184022.4.
DR Ensembl; ENST00000642090.1; ENSP00000493236.1; ENSG00000184022.4.
DR GeneID; 127069; -.
DR KEGG; hsa:127069; -.
DR MANE-Select; ENST00000642090.1; ENSP00000493236.1; NM_001004693.2; NP_001004693.1.
DR UCSC; uc010pzn.2; human.
DR CTD; 127069; -.
DR GeneCards; OR2T10; -.
DR HGNC; HGNC:19573; OR2T10.
DR HPA; ENSG00000184022; Tissue enriched (kidney).
DR neXtProt; NX_Q8NGZ9; -.
DR OpenTargets; ENSG00000184022; -.
DR PharmGKB; PA134982857; -.
DR VEuPathDB; HostDB:ENSG00000184022; -.
DR eggNOG; ENOG502T92Q; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGZ9; -.
DR OMA; MLRMQKA; -.
DR OrthoDB; 1039038at2759; -.
DR PhylomeDB; Q8NGZ9; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NGZ9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 127069; 6 hits in 671 CRISPR screens.
DR GeneWiki; OR2T10; -.
DR GenomeRNAi; 127069; -.
DR Pharos; Q8NGZ9; Tdark.
DR PRO; PR:Q8NGZ9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGZ9; protein.
DR Bgee; ENSG00000184022; Expressed in adult mammalian kidney and 6 other tissues.
DR ExpressionAtlas; Q8NGZ9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2T10"
FT /id="PRO_0000150502"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35403 MW; E3E0D477D87702BF CRC64;
MRLANQTLGG DFFLLGIFSQ ISHPGRLCLL IFSIFLMAVS WNITLILLIH IDSSLHTPMY
FFINQLSLID LTYISVTVPK MLVNQLAKDK TISVLGCGTQ MYFYLQLGGA ECCLLAAMAY
DRYVAICHPL RYSVLMSHRV CLLLASGCWF VGSVDGFMLT PIAMSFPFCR SHEIQHFFCE
VPAVLKLSCS DTSLYKIFMY LCCVIMLLIP VTVISVSYYY IILTIHKMNS VEGRKKAFTT
CSSHITVVSL FYGAAIYNYM LPSSYQTPEK DMMSSFFYTI LTPVLNPIIY SFRNKDVTRA
LKKMLSVQKP PY
