O2T11_HUMAN
ID O2T11_HUMAN Reviewed; 316 AA.
AC Q8NH01; B9EIN4; Q6IEY6;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 2T11;
DE AltName: Full=Olfactory receptor OR1-65;
GN Name=OR2T11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-119 AND ARG-309.
RX PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT "Human olfactory receptor responses to odorants.";
RL Sci. Data 2:150002-150002(2015).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ARG-119 AND
RP ARG-309.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-119 AND ARG-309.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T11";
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DR EMBL; AB065614; BAC05841.1; -; Genomic_DNA.
DR EMBL; KP290143; ALI87331.1; -; Genomic_DNA.
DR EMBL; KP290144; ALI87332.1; -; Genomic_DNA.
DR EMBL; CH471257; EAW57529.1; -; Genomic_DNA.
DR EMBL; BC140749; AAI40750.1; -; mRNA.
DR EMBL; BK004476; DAA04874.1; -; Genomic_DNA.
DR RefSeq; NP_001001964.1; NM_001001964.1.
DR AlphaFoldDB; Q8NH01; -.
DR SMR; Q8NH01; -.
DR BioGRID; 126039; 1.
DR IntAct; Q8NH01; 1.
DR STRING; 9606.ENSP00000328934; -.
DR GlyGen; Q8NH01; 1 site.
DR BioMuta; OR2T11; -.
DR DMDM; 38503049; -.
DR jPOST; Q8NH01; -.
DR MassIVE; Q8NH01; -.
DR PaxDb; Q8NH01; -.
DR PeptideAtlas; Q8NH01; -.
DR PRIDE; Q8NH01; -.
DR ProteomicsDB; 73637; -.
DR Antibodypedia; 79204; 104 antibodies from 23 providers.
DR DNASU; 127077; -.
DR Ensembl; ENST00000641193.1; ENSP00000492951.1; ENSG00000279301.5.
DR GeneID; 127077; -.
DR KEGG; hsa:127077; -.
DR MANE-Select; ENST00000641193.1; ENSP00000492951.1; NM_001001964.2; NP_001001964.1.
DR UCSC; uc001ier.1; human.
DR CTD; 127077; -.
DR GeneCards; OR2T11; -.
DR HGNC; HGNC:19574; OR2T11.
DR HPA; ENSG00000279301; Not detected.
DR neXtProt; NX_Q8NH01; -.
DR PharmGKB; PA134948800; -.
DR VEuPathDB; HostDB:ENSG00000279301; -.
DR eggNOG; ENOG502SMQD; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NH01; -.
DR OMA; FLIHMDS; -.
DR OrthoDB; 984135at2759; -.
DR PhylomeDB; Q8NH01; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NH01; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH01; -.
DR BioGRID-ORCS; 127077; 9 hits in 669 CRISPR screens.
DR GeneWiki; OR2T11; -.
DR GenomeRNAi; 127077; -.
DR Pharos; Q8NH01; Tdark.
DR PRO; PR:Q8NH01; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NH01; protein.
DR Bgee; ENSG00000279301; Expressed in kidney and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 2T11"
FT /id="PRO_0000150503"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 119
FT /note="C -> R (in dbSNP:rs1892443)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809, ECO:0000269|Ref.3"
FT /id="VAR_053155"
FT VARIANT 309
FT /note="Q -> R (in dbSNP:rs1892442)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809, ECO:0000269|Ref.3"
FT /id="VAR_053156"
SQ SEQUENCE 316 AA; 34797 MW; E785C0F88F405FD8 CRC64;
MTNTSSSDFT LLGLLVNSEA AGIVFTVILA VFLGAVTANL VMIFLIQVDS RLHTPMYFLL
SQLSIMDTLF ICTTVPKLLA DMVSKEKIIS FVACGIQIFL YLTMIGSEFF LLGLMAYDCY
VAVCNPLRYP VLMNRKKCLL LAAGAWFGGS LDGFLLTPIT MNVPYCGSRS INHFFCEIPA
VLKLACADTS LYETLMYICC VLMLLIPISI ISTSYSLILL TIHRMPSAEG RKKAFTTCSS
HLTVVSIFYG AAFYTYVLPQ SFHTPEQDKV VSAFYTIVTP MLNPLIYSLR NKDVIGAFKK
VFACCSSAQK VATSDA
