O2T12_HUMAN
ID O2T12_HUMAN Reviewed; 320 AA.
AC Q8NG77;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Olfactory receptor 2T12;
DE AltName: Full=Olfactory receptor OR1-57;
GN Name=OR2T12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T12";
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DR EMBL; AB065960; BAC06172.1; -; Genomic_DNA.
DR EMBL; AL450303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004485; DAA04883.1; -; Genomic_DNA.
DR CCDS; CCDS31110.1; -.
DR RefSeq; NP_001004692.1; NM_001004692.1.
DR AlphaFoldDB; Q8NG77; -.
DR SMR; Q8NG77; -.
DR BioGRID; 126034; 1.
DR STRING; 9606.ENSP00000324583; -.
DR GlyGen; Q8NG77; 1 site.
DR BioMuta; OR2T12; -.
DR DMDM; 71153027; -.
DR MassIVE; Q8NG77; -.
DR PaxDb; Q8NG77; -.
DR PeptideAtlas; Q8NG77; -.
DR PRIDE; Q8NG77; -.
DR Antibodypedia; 71735; 25 antibodies from 10 providers.
DR DNASU; 127064; -.
DR Ensembl; ENST00000641276.1; ENSP00000493000.1; ENSG00000177201.3.
DR GeneID; 127064; -.
DR KEGG; hsa:127064; -.
DR MANE-Select; ENST00000641276.1; ENSP00000493000.1; NM_001004692.2; NP_001004692.1.
DR UCSC; uc010pzj.2; human.
DR CTD; 127064; -.
DR DisGeNET; 127064; -.
DR GeneCards; OR2T12; -.
DR HGNC; HGNC:19592; OR2T12.
DR HPA; ENSG00000177201; Tissue enhanced (brain).
DR neXtProt; NX_Q8NG77; -.
DR PharmGKB; PA134941840; -.
DR VEuPathDB; HostDB:ENSG00000177201; -.
DR eggNOG; ENOG502RU0Z; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG77; -.
DR OMA; CMDQCAA; -.
DR OrthoDB; 1004458at2759; -.
DR PhylomeDB; Q8NG77; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NG77; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NG77; -.
DR BioGRID-ORCS; 127064; 5 hits in 607 CRISPR screens.
DR GeneWiki; OR2T12; -.
DR GenomeRNAi; 127064; -.
DR Pharos; Q8NG77; Tdark.
DR PRO; PR:Q8NG77; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NG77; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 2T12"
FT /id="PRO_0000150504"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 41
FT /note="A -> S (in dbSNP:rs12135684)"
FT /id="VAR_060003"
FT VARIANT 69
FT /note="M -> V (in dbSNP:rs6678138)"
FT /id="VAR_060004"
FT VARIANT 104
FT /note="T -> S (in dbSNP:rs12137982)"
FT /id="VAR_060005"
FT VARIANT 296
FT /note="K -> N (in dbSNP:rs11204625)"
FT /id="VAR_053157"
FT VARIANT 301
FT /note="R -> L (in dbSNP:rs6667171)"
FT /id="VAR_060006"
SQ SEQUENCE 320 AA; 35946 MW; DD6281B07E95F2EE CRC64;
MEMRNTTPDF ILLGLFNHTR AHQVLFMMLL ATVLTSLFSN ALMILLIHWD HRLHRPMYFL
LSQLSLMDMM LVSTTVPKMA ADYLTGNKAI SRAGCGVQIF FLPTLGGGEC FLLAAMAYDR
YAAVCHPLRY PTLMSWQLCL RMTMSSWLLG AADGLLQAVA TLSFPYCGAH EIDHFFCEAP
VLVRLACADT SVFENAMYIC CVLMLLVPFS LILSSYGLIL AAVLLMRSTE ARKKAFATCS
SHVAVVGLFY GAGIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV RNSEVKEALK
RWLGTCVNLK HQQNEAHRSR
