ID   O2T27_HUMAN             Reviewed;         317 AA.
AC   Q8NH04;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Olfactory receptor 2T27;
DE   AltName: Full=Olfactory receptor OR1-67;
GN   Name=OR2T27;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T27";
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DR   EMBL; AB065611; BAC05838.1; -; Genomic_DNA.
DR   EMBL; BK004474; DAA04872.1; -; Genomic_DNA.
DR   CCDS; CCDS31124.1; -.
DR   RefSeq; NP_001001824.1; NM_001001824.1.
DR   AlphaFoldDB; Q8NH04; -.
DR   SMR; Q8NH04; -.
DR   STRING; 9606.ENSP00000342008; -.
DR   GlyGen; Q8NH04; 1 site.
DR   iPTMnet; Q8NH04; -.
DR   PhosphoSitePlus; Q8NH04; -.
DR   BioMuta; OR2T27; -.
DR   DMDM; 73621333; -.
DR   MassIVE; Q8NH04; -.
DR   PaxDb; Q8NH04; -.
DR   PeptideAtlas; Q8NH04; -.
DR   PRIDE; Q8NH04; -.
DR   ProteomicsDB; 73640; -.
DR   Antibodypedia; 57448; 68 antibodies from 18 providers.
DR   DNASU; 403239; -.
DR   Ensembl; ENST00000460972.4; ENSP00000493412.1; ENSG00000187701.5.
DR   Ensembl; ENST00000641652.1; ENSP00000493434.1; ENSG00000187701.5.
DR   GeneID; 403239; -.
DR   KEGG; hsa:403239; -.
DR   MANE-Select; ENST00000460972.4; ENSP00000493412.1; NM_001001824.2; NP_001001824.1.
DR   UCSC; uc010pzo.2; human.
DR   CTD; 403239; -.
DR   GeneCards; OR2T27; -.
DR   HGNC; HGNC:31252; OR2T27.
DR   HPA; ENSG00000187701; Not detected.
DR   neXtProt; NX_Q8NH04; -.
DR   PharmGKB; PA134945560; -.
DR   VEuPathDB; HostDB:ENSG00000187701; -.
DR   eggNOG; ENOG502SMQD; Eukaryota.
DR   GeneTree; ENSGT01050000244844; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q8NH04; -.
DR   OMA; STYETAM; -.
DR   OrthoDB; 916030at2759; -.
DR   PhylomeDB; Q8NH04; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q8NH04; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NH04; -.
DR   BioGRID-ORCS; 403239; 11 hits in 586 CRISPR screens.
DR   GeneWiki; OR2T27; -.
DR   GenomeRNAi; 403239; -.
DR   Pharos; Q8NH04; Tdark.
DR   PRO; PR:Q8NH04; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NH04; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..317
FT                   /note="Olfactory receptor 2T27"
FT                   /id="PRO_0000150505"
FT   TOPO_DOM        1..22
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         36
FT                   /note="L -> V (in dbSNP:rs1782242)"
FT                   /id="VAR_053158"
FT   VARIANT         45
FT                   /note="K -> M (in dbSNP:rs28533004)"
FT                   /id="VAR_062030"
SQ   SEQUENCE   317 AA;  35514 MW;  E271C5F00CFDE7F7 CRC64;
     MEQSNYSVYA DFILLGLFSN ARFPWLLFAL ILLVFLTSIA SNVVKIILIH IDSRLHTPMY
     FLLSQLSLRD ILYISTIVPK MLVDQVMSQR AISFAGCTAQ HFLYLTLAGA EFFLLGLMSY
     DRYVAICNPL HYPVLMSRKI CWLIVAAAWL GGSIDGFLLT PVTMQFPFCA SREINHFFCE
     VPALLKLSCT DTSAYETAMY VCCIMMLLIP FSVISGSYTR ILITVYRMSE AEGRGKAVAT
     CSSHMVVVSL FYGAAMYTYV LPHSYHTPEQ DKAVSAFYTI LTPMLNPLIY SLRNKDVTGA
     LQKVVGRCVS SGKVTTF