O2T29_HUMAN
ID O2T29_HUMAN Reviewed; 315 AA.
AC Q8NH02;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 2T29;
GN Name=OR2T29;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05840.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T29";
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DR EMBL; AB065613; BAC05840.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS55695.1; -.
DR RefSeq; NP_001004694.2; NM_001004694.2.
DR AlphaFoldDB; Q8NH02; -.
DR SMR; Q8NH02; -.
DR BioGRID; 131265; 1.
DR STRING; 9606.ENSP00000331774; -.
DR GlyGen; Q8NH02; 2 sites.
DR iPTMnet; Q8NH02; -.
DR PhosphoSitePlus; Q8NH02; -.
DR BioMuta; OR2T29; -.
DR DMDM; 38372798; -.
DR MassIVE; Q8NH02; -.
DR PaxDb; Q8NH02; -.
DR PeptideAtlas; Q8NH02; -.
DR PRIDE; Q8NH02; -.
DR ProteomicsDB; 73638; -.
DR Antibodypedia; 57443; 25 antibodies from 16 providers.
DR DNASU; 343563; -.
DR Ensembl; ENST00000328570.6; ENSP00000331774.3; ENSG00000182783.6.
DR Ensembl; ENST00000641069.1; ENSP00000492895.1; ENSG00000182783.6.
DR GeneID; 343563; -.
DR KEGG; hsa:343563; -.
DR MANE-Select; ENST00000641069.1; ENSP00000492895.1; NM_001004694.3; NP_001004694.2.
DR UCSC; uc001ieo.2; human.
DR CTD; 343563; -.
DR GeneCards; OR2T29; -.
DR HGNC; HGNC:31253; OR2T29.
DR HPA; ENSG00000182783; Not detected.
DR neXtProt; NX_Q8NH02; -.
DR PharmGKB; PA134876557; -.
DR VEuPathDB; HostDB:ENSG00000182783; -.
DR eggNOG; ENOG502T92P; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH02; -.
DR OMA; CKTREIH; -.
DR OrthoDB; 1039038at2759; -.
DR PhylomeDB; Q8NH02; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NH02; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH02; -.
DR BioGRID-ORCS; 343563; 82 hits in 584 CRISPR screens.
DR GenomeRNAi; 343563; -.
DR Pharos; Q8NH02; Tdark.
DR PRO; PR:Q8NH02; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NH02; protein.
DR Bgee; ENSG00000182783; Expressed in vermiform appendix and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 2T29"
FT /id="PRO_0000150506"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 315 AA; 35595 MW; E8AFED7EC21079CD CRC64;
MANITRMANH TGRLDFILMG LFRQSKHPAL LSVVIFVVFL KALSGNAVLI LLIHCDAHLH
SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE CGMQMFLYLT LAGSEFFLLA
TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS GCWFLGSVDG FMLTPITMSF PFCRSWEIHH
FFCEVPAVTI LSCSDTSLYE TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK
AFATCSSHLT VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD
VMGALKKMLT VRFVL
