O2T34_HUMAN
ID O2T34_HUMAN Reviewed; 318 AA.
AC Q8NGX1; B2RNJ8; Q6IEY5; Q96R31;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 2T34;
DE AltName: Full=Olfactory receptor OR1-63;
GN Name=OR2T34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-267.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-289, AND VARIANT PRO-267.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04875.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T34";
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DR EMBL; AB065645; BAC05871.1; -; Genomic_DNA.
DR EMBL; AC098483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471257; EAW57527.1; -; Genomic_DNA.
DR EMBL; CH471148; EAW77228.1; -; Genomic_DNA.
DR EMBL; BC136926; AAI36927.1; -; mRNA.
DR EMBL; AF399612; AAK95097.1; -; Genomic_DNA.
DR EMBL; BK004477; DAA04875.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31120.1; -.
DR RefSeq; NP_001001821.1; NM_001001821.1.
DR AlphaFoldDB; Q8NGX1; -.
DR SMR; Q8NGX1; -.
DR STRING; 9606.ENSP00000330904; -.
DR GlyGen; Q8NGX1; 2 sites.
DR BioMuta; OR2T34; -.
DR DMDM; 51339202; -.
DR MassIVE; Q8NGX1; -.
DR PaxDb; Q8NGX1; -.
DR PeptideAtlas; Q8NGX1; -.
DR PRIDE; Q8NGX1; -.
DR Antibodypedia; 71738; 1 antibodies from 1 providers.
DR DNASU; 127068; -.
DR Ensembl; ENST00000328782.3; ENSP00000330904.2; ENSG00000183310.3.
DR GeneID; 127068; -.
DR KEGG; hsa:127068; -.
DR MANE-Select; ENST00000328782.3; ENSP00000330904.2; NM_001001821.1; NP_001001821.1.
DR UCSC; uc001iep.1; human.
DR CTD; 127068; -.
DR GeneCards; OR2T34; -.
DR HGNC; HGNC:31256; OR2T34.
DR HPA; ENSG00000183310; Not detected.
DR neXtProt; NX_Q8NGX1; -.
DR PharmGKB; PA134944535; -.
DR VEuPathDB; HostDB:ENSG00000183310; -.
DR eggNOG; ENOG502T92R; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGX1; -.
DR OMA; CYDISLY; -.
DR OrthoDB; 963616at2759; -.
DR PhylomeDB; Q8NGX1; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NGX1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 127068; 9 hits in 586 CRISPR screens.
DR GeneWiki; OR2T34; -.
DR GenomeRNAi; 127068; -.
DR Pharos; Q8NGX1; Tdark.
DR PRO; PR:Q8NGX1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGX1; protein.
DR Bgee; ENSG00000183310; Expressed in adult mammalian kidney and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 2T34"
FT /id="PRO_0000150508"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 267
FT /note="R -> P (in dbSNP:rs1770107)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_067439"
SQ SEQUENCE 318 AA; 35681 MW; E804D51F54F58C0F CRC64;
MCSGNQTSQN QTASTDFTLT GLFAESKHAA LLYTVTFLLF LMALTGNALL ILLIHSEPRL
HTPMYFFISQ LALMDLMYLC VTVPKMLVGQ VTGDDTISPS GCGIQMFFHL TLAGAEVFLL
AAMAYDRYAA VCRPLHYPLL MNQRVCQLLV SACWVLGMVD GLLLTPITMS FPFCQSRKIL
SFFCETPALL KLSCSDVSLY KMLTYLCCIL MLLTPIMVIS SSYTLILHLI HRMNSAAGRR
KALATCSSHM IIVLLLFGAS FYTYMLRSSY HTAEQDMMVS AFYTIFTPVL NPLIYSLRNK
DVTRALRSMM QSRMNQEK
