O2T35_HUMAN
ID O2T35_HUMAN Reviewed; 323 AA.
AC Q8NGX2; Q6IEY7;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 2T35;
DE AltName: Full=Olfactory receptor OR1-66;
GN Name=OR2T35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T35";
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DR EMBL; AB065644; BAC05870.1; -; Genomic_DNA.
DR EMBL; BK004475; DAA04873.1; -; Genomic_DNA.
DR CCDS; CCDS31123.1; -.
DR RefSeq; NP_001001827.1; NM_001001827.1.
DR AlphaFoldDB; Q8NGX2; -.
DR SMR; Q8NGX2; -.
DR BioGRID; 135579; 2.
DR IntAct; Q8NGX2; 1.
DR STRING; 9606.ENSP00000324369; -.
DR GlyGen; Q8NGX2; 1 site.
DR iPTMnet; Q8NGX2; -.
DR PhosphoSitePlus; Q8NGX2; -.
DR BioMuta; OR2T35; -.
DR DMDM; 38258180; -.
DR MassIVE; Q8NGX2; -.
DR PaxDb; Q8NGX2; -.
DR PRIDE; Q8NGX2; -.
DR Antibodypedia; 57447; 85 antibodies from 20 providers.
DR DNASU; 403244; -.
DR Ensembl; ENST00000641268.1; ENSP00000492995.1; ENSG00000177151.5.
DR GeneID; 403244; -.
DR KEGG; hsa:403244; -.
DR MANE-Select; ENST00000641268.1; ENSP00000492995.1; NM_001001827.2; NP_001001827.1.
DR UCSC; uc001ies.1; human.
DR CTD; 403244; -.
DR GeneCards; OR2T35; -.
DR HGNC; HGNC:31257; OR2T35.
DR HPA; ENSG00000177151; Not detected.
DR neXtProt; NX_Q8NGX2; -.
DR PharmGKB; PA134968902; -.
DR VEuPathDB; HostDB:ENSG00000177151; -.
DR eggNOG; ENOG502T9MD; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGX2; -.
DR OMA; CASRHIN; -.
DR OrthoDB; 914755at2759; -.
DR PhylomeDB; Q8NGX2; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NGX2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGX2; -.
DR BioGRID-ORCS; 403244; 5 hits in 583 CRISPR screens.
DR GenomeRNAi; 403244; -.
DR Pharos; Q8NGX2; Tdark.
DR PRO; PR:Q8NGX2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGX2; protein.
DR Bgee; ENSG00000177151; Expressed in kidney and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 2T35"
FT /id="PRO_0000150509"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 323 AA; 36101 MW; 4F6ADED325AF9E79 CRC64;
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA VVFSIFVVAI TANLVMILLI HMDSRLHTPM
YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV QIFYLTLIGG EFFLLGLMAY
DRYVAVCNPL RYPLLMNRRV CLFMVVGSWV GGSLDGFMLT PVTMSFPFCR SREINHFFCE
IPAVLKLSCT DTSLYETLMY ACCVLMLLIP LSVISVSYTH ILLTVHRMNS AEGRRKAFAT
CSSHIMVVSV FYGAAFYTNV LPHSYHTPEK DKVVSAFYTI LTPMLNPLIY SLRNKDVAAA
LRKVLGRCGS SQSIRVATVI RKG
