ID   O3628_CONAE             Reviewed;          39 AA.
AC   Q9BP50;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Conotoxin ArMSGL-013;
DE   Flags: Precursor; Fragment;
OS   Conus arenatus (Sand-dusted cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O3 superfamily. {ECO:0000305}.
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DR   EMBL; AF215107; AAG60528.1; -; mRNA.
DR   AlphaFoldDB; Q9BP50; -.
DR   SMR; Q9BP50; -.
DR   ConoServer; 785; Ar6.28 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Knottin;
KW   Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..5
FT                   /id="PRO_0000404860"
FT   PEPTIDE         8..38
FT                   /note="Conotoxin ArMSGL-013"
FT                   /id="PRO_0000404861"
FT   MOD_RES         38
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        12..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..33
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..37
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   39 AA;  4551 MW;  1C4D2343C0BC115E CRC64;
     RRSLTRRVPE ECEESCEEEE KTCCGLENGQ PFCSRICWG