O366_CONTS
ID O366_CONTS Reviewed; 78 AA.
AC Q9BP74;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Conotoxin TsMSGL-12;
DE Flags: Precursor;
OS Conus tessulatus (Tessellate cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX NCBI_TaxID=101317;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL Mol. Biol. Evol. 18:120-131(2001).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O3 superfamily. {ECO:0000305}.
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DR EMBL; AF215064; AAG60492.1; -; mRNA.
DR AlphaFoldDB; Q9BP74; -.
DR ConoServer; 751; Ts6.6 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Knottin;
KW Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..44
FT /evidence="ECO:0000250"
FT /id="PRO_0000404866"
FT PEPTIDE 47..77
FT /note="Conotoxin TsMSGL-12"
FT /id="PRO_0000404867"
FT MOD_RES 77
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT DISULFID 51..63
FT /evidence="ECO:0000250"
FT DISULFID 55..72
FT /evidence="ECO:0000250"
FT DISULFID 62..76
FT /evidence="ECO:0000250"
SQ SEQUENCE 78 AA; 8856 MW; C705271214E75C56 CRC64;
MSGLGIMVLT LLLFMFMATS HQDAGEKQAT QRDAINVRRR RSITRRGDEE CNEYCDDRNK
ECCGRTNGHP RCANVCFG