ID   O373_CONLI              Reviewed;          79 AA.
AC   Q3YED3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Conotoxin LiCr173;
DE   Flags: Precursor;
OS   Conus lividus (Livid cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=89426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT PHE-78.
RC   TISSUE=Venom duct;
RX   PubMed=17177885; DOI=10.1111/j.1747-0285.2006.00443.x;
RA   Zhangsun D., Luo S., Wu Y., Zhu X., Hu Y., Xie L.;
RT   "Novel O-superfamily conotoxins identified by cDNA cloning from three
RT   vermivorous Conus species.";
RL   Chem. Biol. Drug Des. 68:256-265(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O3 superfamily. {ECO:0000305}.
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DR   EMBL; DQ141180; AAZ83779.2; -; mRNA.
DR   AlphaFoldDB; Q3YED3; -.
DR   ConoServer; 2722; LiCr173 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..46
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000315484"
FT   PEPTIDE         47..78
FT                   /note="Conotoxin LiCr173"
FT                   /id="PRO_0000315485"
FT   MOD_RES         78
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17177885"
FT   DISULFID        52..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..77
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8928 MW;  DBBFDE946D597A50 CRC64;
     MSGLGTMVLT LLLLVFMVTS HQDGGKKQAT QRNAVNIRRR KSITQRTTDE KCNEYCEERD
     RNCCGKANGE PRCARMCFG