O3L4_ARATH
ID O3L4_ARATH Reviewed; 240 AA.
AC Q8L9W8; Q84WC9;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein OXIDATIVE STRESS 3 LIKE 4 {ECO:0000303|PubMed:18980652};
DE Short=AtO3L4 {ECO:0000303|PubMed:18980652};
DE AltName: Full=KID-containing protein {ECO:0000303|PubMed:12631331};
DE Short=AtKCP {ECO:0000303|PubMed:12631331};
GN Name=O3L4 {ECO:0000303|PubMed:18980652};
GN Synonyms=KCP {ECO:0000303|PubMed:12631331};
GN OrderedLocusNames=At5g24890 {ECO:0000312|Araport:AT5G24890};
GN ORFNames=F6A4.100 {ECO:0000312|EMBL:AED93375.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=12631331; DOI=10.1046/j.1365-313x.2003.01694.x;
RA Gao M.-J., Schaefer U.A., Parkin I.A.P., Hegedus D.D., Lydiate D.J.,
RA Hannoufa A.;
RT "A novel protein from Brassica napus has a putative KID domain and responds
RT to low temperature.";
RL Plant J. 33:1073-1086(2003).
RN [6]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Landsberg erecta, and cv. Wassilewskija;
RX PubMed=18980652; DOI=10.1111/j.1365-313x.2008.03717.x;
RA Blanvillain R., Kim J.H., Wu S., Lima A., Ow D.W.;
RT "OXIDATIVE STRESS 3 is a chromatin-associated factor involved in tolerance
RT to heavy metals and oxidative stress.";
RL Plant J. 57:654-665(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Transcription activator which may regulates gene expression
CC through interaction with the histone deacetylase HDA19 (By similarity).
CC Promotes slightly the tolerance to cadmium (Cd) and to oxidizing
CC chemicals (e.g. diamide and tert-butyl hydroperoxide (t-BOOH))
CC (PubMed:18980652). {ECO:0000250|UniProtKB:Q84U09,
CC ECO:0000269|PubMed:18980652}.
CC -!- SUBUNIT: Interacts with HDA19; Ser-213 is critical for this
CC interaction. {ECO:0000250|UniProtKB:Q84U09}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9LVB9}.
CC -!- DOMAIN: The kinase-inducible domain (KID, 202-229) is required for
CC interaction with HDA19. {ECO:0000250|UniProtKB:Q84U09}.
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DR EMBL; CP002688; AED93375.1; -; Genomic_DNA.
DR EMBL; AY088175; AAM65718.1; -; mRNA.
DR EMBL; BT003969; AAO42013.1; -; mRNA.
DR EMBL; BT020475; AAW38976.1; -; mRNA.
DR EMBL; BT023742; AAZ23934.1; -; mRNA.
DR RefSeq; NP_197871.1; NM_122398.4.
DR AlphaFoldDB; Q8L9W8; -.
DR STRING; 3702.AT5G24890.1; -.
DR PaxDb; Q8L9W8; -.
DR PRIDE; Q8L9W8; -.
DR ProteomicsDB; 182990; -.
DR EnsemblPlants; AT5G24890.1; AT5G24890.1; AT5G24890.
DR GeneID; 832558; -.
DR Gramene; AT5G24890.1; AT5G24890.1; AT5G24890.
DR KEGG; ath:AT5G24890; -.
DR Araport; AT5G24890; -.
DR TAIR; locus:2149413; AT5G24890.
DR eggNOG; KOG4210; Eukaryota.
DR HOGENOM; CLU_066544_2_0_1; -.
DR InParanoid; Q8L9W8; -.
DR OMA; DTDNNSY; -.
DR OrthoDB; 1263702at2759; -.
DR PhylomeDB; Q8L9W8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L9W8; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0046686; P:response to cadmium ion; IMP:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Phosphoprotein; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..240
FT /note="Protein OXIDATIVE STRESS 3 LIKE 4"
FT /id="PRO_0000455035"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..229
FT /note="Kinase-inducible domain (KID)"
FT /evidence="ECO:0000250|UniProtKB:Q84U09"
FT MOTIF 142..150
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 11..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 213
FT /note="Critical for interaction with HDA19"
FT /evidence="ECO:0000250|UniProtKB:Q84U09"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q84U09"
FT CONFLICT 182
FT /note="D -> E (in Ref. 3; AAO42013)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 26577 MW; 5A4143571BF732A3 CRC64;
MELMAKPTFS IEVSQYGTTD LPATEKASSS SSSFETTNEE GVEESGLSRI WSGQTADYSS
DSSSIGTPGD SEEDEEESEN ENDDVSSKEL GLRGLASMSS LEDSLPSKRG LSNHYKGKSK
SFGNLGEIGS VKEVAKQENP LNKRRRLQIC NKLARKSFYS WQNPKSMPLL PVNEDEDDDD
EDDDEEDLKS GFDENKSSSD EEGVKKVVVR KGSFKNRAYK SRSCFALSDL IEEEDDDDDQ
