O4A15_HUMAN
ID O4A15_HUMAN Reviewed; 344 AA.
AC Q8NGL6; Q6IFL4; Q96R65;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 4A15;
DE AltName: Full=Olfactory receptor OR11-118;
GN Name=OR4A15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-308.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-31 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04646.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4A15";
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DR EMBL; AB065776; BAC05996.1; -; Genomic_DNA.
DR EMBL; AP005639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399578; AAK95063.1; -; Genomic_DNA.
DR EMBL; BK004248; DAA04646.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001005275.1; NM_001005275.1.
DR AlphaFoldDB; Q8NGL6; -.
DR SMR; Q8NGL6; -.
DR BioGRID; 123450; 1.
DR STRING; 9606.ENSP00000325065; -.
DR GlyGen; Q8NGL6; 2 sites.
DR iPTMnet; Q8NGL6; -.
DR PhosphoSitePlus; Q8NGL6; -.
DR BioMuta; OR4A15; -.
DR DMDM; 229462945; -.
DR EPD; Q8NGL6; -.
DR jPOST; Q8NGL6; -.
DR MaxQB; Q8NGL6; -.
DR PaxDb; Q8NGL6; -.
DR PeptideAtlas; Q8NGL6; -.
DR PRIDE; Q8NGL6; -.
DR ProteomicsDB; 73549; -.
DR DNASU; 81328; -.
DR GeneID; 81328; -.
DR KEGG; hsa:81328; -.
DR UCSC; uc010rif.2; human.
DR CTD; 81328; -.
DR GeneCards; OR4A15; -.
DR HGNC; HGNC:15152; OR4A15.
DR neXtProt; NX_Q8NGL6; -.
DR PharmGKB; PA32234; -.
DR eggNOG; ENOG502TEH8; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGL6; -.
DR OrthoDB; 1107575at2759; -.
DR PhylomeDB; Q8NGL6; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGL6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81328; 19 hits in 667 CRISPR screens.
DR GeneWiki; OR4A15; -.
DR GenomeRNAi; 81328; -.
DR Pharos; Q8NGL6; Tdark.
DR PRO; PR:Q8NGL6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL6; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..344
FT /note="Olfactory receptor 4A15"
FT /id="PRO_0000150525"
FT TOPO_DOM 1..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..317
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 125..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 26
FT /note="P -> S (in dbSNP:rs1425193)"
FT /id="VAR_055053"
FT VARIANT 287
FT /note="A -> V (in dbSNP:rs7927370)"
FT /id="VAR_055054"
SQ SEQUENCE 344 AA; 38828 MW; AF3D1A6A05738B16 CRC64;
MELLTNNLKF ITDPFVCRLR HLSPTPSEEH MKNKNNVTEF ILLGLTQNPE GQKVLFVTFL
LIYMVTIMGN LLIIVTIMAS QSLGSPMYFF LASLSFIDTV YSTAFAPKMI VDLLSEKKTI
SFQGCMAQLF MDHLFAGAEV ILLVVMAYDR YMAICKPLHE LITMNRRVCV LMLLAAWIGG
FLHSLVQFLF IYQLPFCGPN VIDNFLCDLY PLLKLACTNT YVTGLSMIAN GGAICAVTFF
TILLSYGVIL HSLKTQSLEG KRKAFYTCAS HVTVVILFFV PCIFLYARPN STFPIDKSMT
VVLTFITPML NPLIYTLKNA EMKSAMRKLW SKKVSLAGKW LYHS
