O4A16_HUMAN
ID O4A16_HUMAN Reviewed; 328 AA.
AC Q8NH70; Q6IFL3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 4A16;
DE AltName: Full=Olfactory receptor OR11-117;
GN Name=OR4A16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4A16";
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DR EMBL; AB065519; BAC05767.1; -; Genomic_DNA.
DR EMBL; BK004249; DAA04647.1; -; Genomic_DNA.
DR CCDS; CCDS31499.1; -.
DR RefSeq; NP_001005274.1; NM_001005274.1.
DR AlphaFoldDB; Q8NH70; -.
DR SMR; Q8NH70; -.
DR BioGRID; 123449; 1.
DR IntAct; Q8NH70; 1.
DR MINT; Q8NH70; -.
DR STRING; 9606.ENSP00000325128; -.
DR GlyGen; Q8NH70; 1 site.
DR iPTMnet; Q8NH70; -.
DR PhosphoSitePlus; Q8NH70; -.
DR BioMuta; OR4A16; -.
DR DMDM; 38372821; -.
DR MassIVE; Q8NH70; -.
DR PaxDb; Q8NH70; -.
DR PeptideAtlas; Q8NH70; -.
DR PRIDE; Q8NH70; -.
DR ProteomicsDB; 73674; -.
DR Antibodypedia; 58928; 55 antibodies from 15 providers.
DR DNASU; 81327; -.
DR Ensembl; ENST00000314721.5; ENSP00000325128.2; ENSG00000181961.5.
DR GeneID; 81327; -.
DR KEGG; hsa:81327; -.
DR MANE-Select; ENST00000314721.5; ENSP00000325128.2; NM_001005274.1; NP_001005274.1.
DR UCSC; uc010rie.2; human.
DR CTD; 81327; -.
DR GeneCards; OR4A16; -.
DR HGNC; HGNC:15153; OR4A16.
DR HPA; ENSG00000181961; Not detected.
DR neXtProt; NX_Q8NH70; -.
DR PharmGKB; PA32235; -.
DR VEuPathDB; HostDB:ENSG00000181961; -.
DR eggNOG; ENOG502SJPV; Eukaryota.
DR GeneTree; ENSGT00940000158620; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH70; -.
DR OMA; WCEKLSI; -.
DR OrthoDB; 965113at2759; -.
DR PhylomeDB; Q8NH70; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NH70; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81327; 9 hits in 665 CRISPR screens.
DR GeneWiki; OR4A16; -.
DR GenomeRNAi; 81327; -.
DR Pharos; Q8NH70; Tdark.
DR PRO; PR:Q8NH70; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH70; protein.
DR ExpressionAtlas; Q8NH70; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..328
FT /note="Olfactory receptor 4A16"
FT /id="PRO_0000150526"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 188
FT /note="L -> I (in dbSNP:rs11229158)"
FT /id="VAR_034187"
FT VARIANT 232
FT /note="H -> R (in dbSNP:rs12807769)"
FT /id="VAR_053164"
FT VARIANT 303
FT /note="K -> M (in dbSNP:rs10896659)"
FT /id="VAR_034188"
SQ SEQUENCE 328 AA; 36922 MW; 033C46B6ABA70E62 CRC64;
MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS PSLGSLMYFF
LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF IEHLLGGAEV FLLVVMAYDR
YVAISKPLHY LNIMNRLVCI LLLVVAMIGG FVHSVVQIVF LYSLPICGPN VIDHSVCDMY
PLLELLCLDT YFIGLTVVAN GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS
HIIVVALVFV PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW
CEKLSIVRKR VSPTLNIFIP SSKATNRR
