ID   O4A47_HUMAN             Reviewed;         309 AA.
AC   Q6IF82;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Olfactory receptor 4A47;
DE   AltName: Full=Olfactory receptor OR11-113;
GN   Name=OR4A47;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4A47";
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DR   EMBL; AC134982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004380; DAA04778.1; -; Genomic_DNA.
DR   CCDS; CCDS31490.1; -.
DR   RefSeq; NP_001005512.2; NM_001005512.2.
DR   AlphaFoldDB; Q6IF82; -.
DR   SMR; Q6IF82; -.
DR   STRING; 9606.ENSP00000412752; -.
DR   GlyGen; Q6IF82; 2 sites.
DR   iPTMnet; Q6IF82; -.
DR   PhosphoSitePlus; Q6IF82; -.
DR   BioMuta; OR4A47; -.
DR   DMDM; 215273863; -.
DR   PaxDb; Q6IF82; -.
DR   PRIDE; Q6IF82; -.
DR   Antibodypedia; 53219; 92 antibodies from 22 providers.
DR   DNASU; 403253; -.
DR   Ensembl; ENST00000446524.2; ENSP00000412752.1; ENSG00000237388.3.
DR   GeneID; 403253; -.
DR   KEGG; hsa:403253; -.
DR   MANE-Select; ENST00000446524.2; ENSP00000412752.1; NM_001005512.2; NP_001005512.2.
DR   UCSC; uc010rhx.3; human.
DR   CTD; 403253; -.
DR   GeneCards; OR4A47; -.
DR   HGNC; HGNC:31266; OR4A47.
DR   HPA; ENSG00000237388; Not detected.
DR   neXtProt; NX_Q6IF82; -.
DR   OpenTargets; ENSG00000237388; -.
DR   PharmGKB; PA134952685; -.
DR   VEuPathDB; HostDB:ENSG00000237388; -.
DR   eggNOG; ENOG502TEH7; Eukaryota.
DR   GeneTree; ENSGT00940000159605; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q6IF82; -.
DR   OMA; CTDTHAI; -.
DR   OrthoDB; 886071at2759; -.
DR   PhylomeDB; Q6IF82; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q6IF82; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 403253; 32 hits in 620 CRISPR screens.
DR   GeneWiki; OR4A47; -.
DR   GenomeRNAi; 403253; -.
DR   Pharos; Q6IF82; Tdark.
DR   PRO; PR:Q6IF82; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6IF82; protein.
DR   Bgee; ENSG00000237388; Expressed in granulocyte and 2 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 4A47"
FT                   /id="PRO_0000150527"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         82
FT                   /note="G -> D (in dbSNP:rs12805819)"
FT                   /id="VAR_047759"
FT   VARIANT         104
FT                   /note="I -> L (in dbSNP:rs7103557)"
FT                   /id="VAR_047760"
FT   VARIANT         145
FT                   /note="V -> M (in dbSNP:rs7103992)"
FT                   /id="VAR_047761"
FT   VARIANT         192
FT                   /note="A -> D (in dbSNP:rs7103932)"
FT                   /id="VAR_047762"
SQ   SEQUENCE   309 AA;  34760 MW;  9E4EB0E0A3C0BCD7 CRC64;
     MEPRKNVTDF VLLGFTQNPK EQKVLFVMFL LFYILTMVGN LLIVVTVTVS ETLGSPMYFF
     LAGLSFIDII YSSSISPRLI SGLFFGNNSI SFQSCMAQLF IEHIFGGSEV FLLLVMAYDC
     YVAICKPLHY LVIMRQWVCV VLLVVSWVGG FLHSVFQLSI IYGLPFCGPN VIDHFFCDMY
     PLLKLVCTDT HAIGLLVVAN GGLACTIVFL LLLISYGVIL HSLKNLSQKG RQKALSTCSS
     HMTVVVFFFV PCIFMYARPA RTFPIDKSVS VFYTVITPML NPLIYTLRNS EMTSAMKKLW
     RRDLISSST