ID   O4C45_HUMAN             Reviewed;         306 AA.
AC   A6NMZ5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Olfactory receptor 4C45;
GN   Name=OR4C45;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- POLYMORPHISM: A stop codon in the gene coding for this protein at
CC       position Tyr-60 is responsible for functional diversity thus producing
CC       a pseudogene. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C45";
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DR   EMBL; AC023080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A6NMZ5; -.
DR   SMR; A6NMZ5; -.
DR   BioMuta; OR4C45; -.
DR   PeptideAtlas; A6NMZ5; -.
DR   PRIDE; A6NMZ5; -.
DR   GeneCards; OR4C45; -.
DR   HGNC; HGNC:31270; OR4C45.
DR   neXtProt; NX_A6NMZ5; -.
DR   InParanoid; A6NMZ5; -.
DR   PhylomeDB; A6NMZ5; -.
DR   PathwayCommons; A6NMZ5; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   Pharos; A6NMZ5; Tdark.
DR   PRO; PR:A6NMZ5; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A6NMZ5; protein.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="Olfactory receptor 4C45"
FT                   /id="PRO_0000312176"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        200..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        92..174
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   306 AA;  33994 MW;  367C8DE02761B70F CRC64;
     MNNVTEFILL GLTHNPELQK FLFVMFLITY LITLAGNLLI SVIIFISPAL GSPMYLFLSY
     LSIIDIFYSS SIAPKMIFDL ISENNTISFN GCMTQLFTEH FFAAAETILL SVMAYDCYVA
     ICKPLHYATI MTQSMCGFLM VVAGILGFVH GGIQTLFIAQ LPFCGPNVID HFMCDLVPLL
     ELACTDTHTL GPLIAANSGS LCFLIFSILD ASYVIILCSL RSHSSEGHLK ALSSCASHIF
     TVILFFVPCS YLYLRPLTSF PTDKAVTVFC TLFTPMLNPL IYTVKNKAVK NVIKKLWKQI
     MTTDDK