O4C46_HUMAN
ID O4C46_HUMAN Reviewed; 309 AA.
AC A6NHA9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Olfactory receptor 4C46;
GN Name=OR4C46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C46";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC126345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73288.1; -.
DR RefSeq; NP_001004703.1; NM_001004703.1.
DR AlphaFoldDB; A6NHA9; -.
DR SMR; A6NHA9; -.
DR STRING; 9606.ENSP00000329056; -.
DR GlyGen; A6NHA9; 1 site.
DR iPTMnet; A6NHA9; -.
DR PhosphoSitePlus; A6NHA9; -.
DR BioMuta; OR4C46; -.
DR PaxDb; A6NHA9; -.
DR PeptideAtlas; A6NHA9; -.
DR PRIDE; A6NHA9; -.
DR Antibodypedia; 78042; 10 antibodies from 8 providers.
DR DNASU; 119749; -.
DR Ensembl; ENST00000328188.1; ENSP00000329056.1; ENSG00000185926.1.
DR GeneID; 119749; -.
DR KEGG; hsa:119749; -.
DR MANE-Select; ENST00000328188.1; ENSP00000329056.1; NM_001004703.1; NP_001004703.1.
DR UCSC; uc010ric.2; human.
DR CTD; 119749; -.
DR DisGeNET; 119749; -.
DR GeneCards; OR4C46; -.
DR HGNC; HGNC:31271; OR4C46.
DR HPA; ENSG00000185926; Not detected.
DR neXtProt; NX_A6NHA9; -.
DR OpenTargets; ENSG00000185926; -.
DR PharmGKB; PA134910149; -.
DR VEuPathDB; HostDB:ENSG00000185926; -.
DR eggNOG; ENOG502TE7F; Eukaryota.
DR GeneTree; ENSGT00940000154261; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; A6NHA9; -.
DR OMA; IHATIQM; -.
DR OrthoDB; 1023410at2759; -.
DR PhylomeDB; A6NHA9; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; A6NHA9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119749; 15 hits in 620 CRISPR screens.
DR ChiTaRS; OR4C46; human.
DR GenomeRNAi; 119749; -.
DR Pharos; A6NHA9; Tdark.
DR PRO; PR:A6NHA9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NHA9; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 4C46"
FT /id="PRO_0000310456"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 240
FT /note="S -> F (in dbSNP:rs11246607)"
FT /id="VAR_037045"
FT VARIANT 252
FT /note="C -> Y (in dbSNP:rs11246608)"
FT /id="VAR_037046"
FT VARIANT 288
FT /note="K -> R (in dbSNP:rs11246609)"
FT /id="VAR_037047"
SQ SEQUENCE 309 AA; 34533 MW; 0A1EF3DBE5FBFAED CRC64;
MENRNNMTEF VLLGLTENPK MQKIIFVVFF VIYIITVVGY VLIVVTITAS PSLGSPMYLS
LAYLSFIDAC YSSVNTPNLI THSLYGKKAI LFNGCMTQVF GEHFFGGAEG ILLTVMAYDH
YVAICKPLHY MTIMNQCVCA LLMGVVWMGG FLHATIQILF IFQLPFCGPN VIDHFMCDLN
PLLNLACTDT HMLELFIAAN SGFICLLNFA LLLVSYVVIL CSLRTHSLEA RHKALSTCVS
HITVVILFFV PCIFVYMRPA ATLPIDKAVA IFYTMITPML NPLIYTLKNA QMKNAIRKLC
SRKDISGDK
