O4F17_HUMAN
ID O4F17_HUMAN Reviewed; 305 AA.
AC Q8NGA8; B2RNE8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 4F17;
DE AltName: Full=Olfactory receptor 4F11;
DE AltName: Full=Olfactory receptor 4F18;
DE AltName: Full=Olfactory receptor 4F19;
GN Name=OR4F17; Synonyms=OR4F11P, OR4F18, OR4F19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F17";
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DR EMBL; AB065917; BAC06132.1; -; Genomic_DNA.
DR EMBL; BC136848; AAI36849.1; -; mRNA.
DR EMBL; BC136867; AAI36868.1; -; mRNA.
DR CCDS; CCDS32854.1; -.
DR RefSeq; NP_001005240.1; NM_001005240.1.
DR RefSeq; XP_005259705.1; XM_005259648.1.
DR AlphaFoldDB; Q8NGA8; -.
DR SMR; Q8NGA8; -.
DR STRING; 9606.ENSP00000467301; -.
DR iPTMnet; Q8NGA8; -.
DR PhosphoSitePlus; Q8NGA8; -.
DR BioMuta; OR4F17; -.
DR DMDM; 38372655; -.
DR PaxDb; Q8NGA8; -.
DR PeptideAtlas; Q8NGA8; -.
DR PRIDE; Q8NGA8; -.
DR Antibodypedia; 59203; 74 antibodies from 21 providers.
DR DNASU; 81099; -.
DR Ensembl; ENST00000318050.4; ENSP00000315047.3; ENSG00000176695.8.
DR Ensembl; ENST00000585993.3; ENSP00000467301.1; ENSG00000176695.8.
DR GeneID; 81099; -.
DR KEGG; hsa:81099; -.
DR MANE-Select; ENST00000585993.3; ENSP00000467301.1; NM_001005240.3; NP_001005240.1.
DR UCSC; uc002loc.2; human.
DR CTD; 81099; -.
DR GeneCards; OR4F17; -.
DR HGNC; HGNC:15381; OR4F17.
DR HPA; ENSG00000176695; Not detected.
DR neXtProt; NX_Q8NGA8; -.
DR OpenTargets; ENSG00000176695; -.
DR PharmGKB; PA32285; -.
DR VEuPathDB; HostDB:ENSG00000176695; -.
DR eggNOG; ENOG502SKZV; Eukaryota.
DR GeneTree; ENSGT00940000162706; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGA8; -.
DR OMA; LRKWDVH; -.
DR OrthoDB; 958833at2759; -.
DR PhylomeDB; Q8NGA8; -.
DR PathwayCommons; Q8NGA8; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81099; 29 hits in 195 CRISPR screens.
DR GenomeRNAi; 81099; -.
DR Pharos; Q8NGA8; Tdark.
DR PRO; PR:Q8NGA8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NGA8; protein.
DR Bgee; ENSG00000176695; Expressed in colonic epithelium and 66 other tissues.
DR ExpressionAtlas; Q8NGA8; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 4F17"
FT /id="PRO_0000150550"
FT TOPO_DOM 1..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..251
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 90..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 305 AA; 34212 MW; 2DDFAC5504EDFA6E CRC64;
MVTEFIFLGL SDSQGLQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS
LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC
KPLHYTTIMC GNACVGIMAV AWGIGFLHSV SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL
ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV
LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH
SSVKF
