O4F21_HUMAN
ID O4F21_HUMAN Reviewed; 312 AA.
AC O95013; A6NIU1;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Olfactory receptor 4F21;
GN Name=OR4F21; Synonyms=OR4F21P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F21";
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DR EMBL; AC131281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004908; AAD05195.1; -; Genomic_DNA.
DR CCDS; CCDS34792.1; -.
DR RefSeq; NP_001005504.1; NM_001005504.1.
DR AlphaFoldDB; O95013; -.
DR SMR; O95013; -.
DR BioGRID; 137346; 1.
DR IntAct; O95013; 1.
DR STRING; 9606.ENSP00000318878; -.
DR GlyGen; O95013; 1 site.
DR iPTMnet; O95013; -.
DR PhosphoSitePlus; O95013; -.
DR BioMuta; OR4F21; -.
DR PaxDb; O95013; -.
DR PRIDE; O95013; -.
DR Antibodypedia; 71356; 24 antibodies from 14 providers.
DR DNASU; 441308; -.
DR Ensembl; ENST00000320901.4; ENSP00000318878.3; ENSG00000176269.4.
DR GeneID; 441308; -.
DR KEGG; hsa:441308; -.
DR MANE-Select; ENST00000320901.4; ENSP00000318878.3; NM_001005504.1; NP_001005504.1.
DR UCSC; uc011kwf.3; human.
DR CTD; 441308; -.
DR GeneCards; OR4F21; -.
DR HGNC; HGNC:19583; OR4F21.
DR HPA; ENSG00000176269; Not detected.
DR neXtProt; NX_O95013; -.
DR PharmGKB; PA134918173; -.
DR VEuPathDB; HostDB:ENSG00000176269; -.
DR eggNOG; ENOG502TEJE; Eukaryota.
DR GeneTree; ENSGT00940000162683; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; O95013; -.
DR OMA; STMSAHI; -.
DR OrthoDB; 947815at2759; -.
DR PhylomeDB; O95013; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; O95013; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O95013; -.
DR BioGRID-ORCS; 441308; 137 hits in 493 CRISPR screens.
DR GenomeRNAi; 441308; -.
DR Pharos; O95013; Tdark.
DR PRO; PR:O95013; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; O95013; protein.
DR Bgee; ENSG00000176269; Expressed in lower esophagus mucosa and 55 other tissues.
DR Genevisible; O95013; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 4F21"
FT /id="PRO_0000150545"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 44
FT /note="F -> L (in Ref. 1; AAD05195)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="K -> R (in Ref. 1; AAD05195)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35094 MW; AC23E27AA9A69586 CRC64;
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT TDPHLHSPMY
FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVIGGV EMVLLIAMAF
DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD
LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL
SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
VCKQLVIYKK IS
