O51A2_HUMAN
ID O51A2_HUMAN Reviewed; 313 AA.
AC Q8NGJ7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 51A2;
GN Name=OR51A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51A2";
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DR EMBL; AB065797; BAC06016.1; -; Genomic_DNA.
DR CCDS; CCDS31368.1; -.
DR RefSeq; NP_001004748.1; NM_001004748.1.
DR AlphaFoldDB; Q8NGJ7; -.
DR SMR; Q8NGJ7; -.
DR STRING; 9606.ENSP00000369729; -.
DR GlyGen; Q8NGJ7; 1 site.
DR BioMuta; OR51A2; -.
DR DMDM; 38372709; -.
DR MassIVE; Q8NGJ7; -.
DR PaxDb; Q8NGJ7; -.
DR PRIDE; Q8NGJ7; -.
DR Antibodypedia; 57570; 54 antibodies from 19 providers.
DR DNASU; 401667; -.
DR Ensembl; ENST00000380371.1; ENSP00000369729.1; ENSG00000205496.1.
DR GeneID; 401667; -.
DR KEGG; hsa:401667; -.
DR MANE-Select; ENST00000380371.1; ENSP00000369729.1; NM_001004748.1; NP_001004748.1.
DR UCSC; uc010qyt.2; human.
DR CTD; 401667; -.
DR GeneCards; OR51A2; -.
DR HGNC; HGNC:14764; OR51A2.
DR HPA; ENSG00000205496; Not detected.
DR neXtProt; NX_Q8NGJ7; -.
DR PharmGKB; PA32355; -.
DR VEuPathDB; HostDB:ENSG00000205496; -.
DR eggNOG; ENOG502RU39; Eukaryota.
DR GeneTree; ENSGT01050000244899; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ7; -.
DR OMA; CPLINSS; -.
DR OrthoDB; 996684at2759; -.
DR PhylomeDB; Q8NGJ7; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGJ7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGJ7; -.
DR BioGRID-ORCS; 401667; 12 hits in 604 CRISPR screens.
DR GenomeRNAi; 401667; -.
DR Pharos; Q8NGJ7; Tdark.
DR PRO; PR:Q8NGJ7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ7; protein.
DR Bgee; ENSG00000205496; Expressed in cardiovascular system and 3 other tissues.
DR ExpressionAtlas; Q8NGJ7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 51A2"
FT /id="PRO_0000150742"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 45
FT /note="G -> C (in dbSNP:rs28482315)"
FT /id="VAR_062075"
FT VARIANT 59
FT /note="G -> E (in dbSNP:rs112749434)"
FT /id="VAR_024138"
FT VARIANT 288
FT /note="M -> T (in dbSNP:rs2442426)"
FT /id="VAR_024139"
FT VARIANT 289
FT /note="K -> N (in dbSNP:rs2570573)"
FT /id="VAR_053305"
SQ SEQUENCE 313 AA; 35078 MW; E5313A140F724F63 CRC64;
MSIINTSYVE ITTFFLVGMP GLEYAHIWIS IPICSMYLIA ILGNGTILFI IKTEPSLHGP
MYYFLSMLAM SDLGLSLSSL PTVLSIFLFN APETSSSACF AQEFFIHGFS VLESSVLLIM
SFDRFLAIHN PLRYTSILTT VRVAQIGIVF SFKSMLLVLP FPFTLRSLRY CKKNQLSHSY
CLHQDVMKLA CSDNRIDVIY GFFGALCLMV DFILIAVSYT LILKTVPGIA SKKEELKALN
TCVSHICAVI IFYLPIINLA VVHRFAGHVS PLINVLMANV LLLVPPLMKP IVYCVKTKQI
RVRVVAKLCQ WKI
