O51A4_HUMAN
ID O51A4_HUMAN Reviewed; 313 AA.
AC Q8NGJ6; B9EIP2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 51A4;
GN Name=OR51A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS CYS-45 AND MET-288.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51A4";
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DR EMBL; AB065798; BAC06017.1; -; Genomic_DNA.
DR EMBL; BC140757; AAI40758.1; -; mRNA.
DR CCDS; CCDS31367.1; -.
DR RefSeq; NP_001005329.1; NM_001005329.1.
DR AlphaFoldDB; Q8NGJ6; -.
DR SMR; Q8NGJ6; -.
DR BioGRID; 135198; 1.
DR STRING; 9606.ENSP00000369731; -.
DR GlyGen; Q8NGJ6; 1 site.
DR iPTMnet; Q8NGJ6; -.
DR PhosphoSitePlus; Q8NGJ6; -.
DR BioMuta; OR51A4; -.
DR DMDM; 38372708; -.
DR MassIVE; Q8NGJ6; -.
DR PaxDb; Q8NGJ6; -.
DR PeptideAtlas; Q8NGJ6; -.
DR PRIDE; Q8NGJ6; -.
DR Antibodypedia; 57568; 43 antibodies from 15 providers.
DR DNASU; 401666; -.
DR Ensembl; ENST00000641898.1; ENSP00000492963.1; ENSG00000205497.5.
DR GeneID; 401666; -.
DR KEGG; hsa:401666; -.
DR MANE-Select; ENST00000641898.1; ENSP00000492963.1; NM_001005329.2; NP_001005329.1.
DR UCSC; uc010qys.2; human.
DR CTD; 401666; -.
DR GeneCards; OR51A4; -.
DR HGNC; HGNC:14795; OR51A4.
DR HPA; ENSG00000205497; Not detected.
DR neXtProt; NX_Q8NGJ6; -.
DR OpenTargets; ENSG00000205497; -.
DR PharmGKB; PA32357; -.
DR VEuPathDB; HostDB:ENSG00000205497; -.
DR eggNOG; ENOG502RU39; Eukaryota.
DR GeneTree; ENSGT01050000244899; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ6; -.
DR OMA; KYCNKSQ; -.
DR OrthoDB; 996684at2759; -.
DR PhylomeDB; Q8NGJ6; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGJ6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 401666; 8 hits in 634 CRISPR screens.
DR GenomeRNAi; 401666; -.
DR Pharos; Q8NGJ6; Tdark.
DR PRO; PR:Q8NGJ6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ6; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 51A4"
FT /id="PRO_0000150743"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 45
FT /note="G -> C (in dbSNP:rs3845246)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062076"
FT VARIANT 72
FT /note="D -> N (in dbSNP:rs2412467)"
FT /id="VAR_053306"
FT VARIANT 267
FT /note="R -> G (in dbSNP:rs2595988)"
FT /id="VAR_034313"
FT VARIANT 288
FT /note="T -> M (in dbSNP:rs28698374)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034314"
FT VARIANT 311
FT /note="R -> W (in dbSNP:rs2436782)"
FT /id="VAR_062077"
SQ SEQUENCE 313 AA; 35256 MW; FCF5290BF79B9BA9 CRC64;
MSIINTSYVE ITTFFLVGMP GLEYAHIWIS IPICSMYLIA ILGNGTILFI IKTEPSLHEP
MYYFLSMLAM SDLGLSLSSL PTVLSIFLFN APEISSNACF AQEFFIHGFS VLESSVLLIM
SFDRFLAIHN PLRYTSILTT VRVAQIGIVF SFKSMLLVLP FPFTLRNLRY CKKNQLSHSY
CLHQDVMKLA CSDNRIDVIY GFFGALCLMV DFILIAVSYT LILKTVLGIA SKKEQLKALN
TCVSHICAVI IFYLPIINLA VVHRFARHVS PLINVLMANV LLLVPPLTNP IVYCVKTKQI
RVRVVAKLCQ RKI
