O51A7_HUMAN
ID O51A7_HUMAN Reviewed; 312 AA.
AC Q8NH64; Q6IFH8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 51A7;
DE AltName: Full=Olfactory receptor OR11-27;
GN Name=OR51A7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51A7";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065525; BAC05773.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68822.1; -; Genomic_DNA.
DR EMBL; BC137062; AAI37063.1; -; mRNA.
DR EMBL; BC137063; AAI37064.1; -; mRNA.
DR EMBL; BK004284; DAA04682.1; -; Genomic_DNA.
DR CCDS; CCDS31364.1; -.
DR RefSeq; NP_001004749.1; NM_001004749.1.
DR AlphaFoldDB; Q8NH64; -.
DR SMR; Q8NH64; -.
DR STRING; 9606.ENSP00000352305; -.
DR GlyGen; Q8NH64; 2 sites.
DR iPTMnet; Q8NH64; -.
DR PhosphoSitePlus; Q8NH64; -.
DR BioMuta; OR51A7; -.
DR DMDM; 38372819; -.
DR PaxDb; Q8NH64; -.
DR PeptideAtlas; Q8NH64; -.
DR PRIDE; Q8NH64; -.
DR Antibodypedia; 57563; 63 antibodies from 16 providers.
DR DNASU; 119687; -.
DR Ensembl; ENST00000359350.5; ENSP00000352305.4; ENSG00000176895.9.
DR Ensembl; ENST00000641490.1; ENSP00000493162.1; ENSG00000176895.9.
DR GeneID; 119687; -.
DR KEGG; hsa:119687; -.
DR MANE-Select; ENST00000641490.1; ENSP00000493162.1; NM_001004749.2; NP_001004749.1.
DR UCSC; uc010qyq.2; human.
DR CTD; 119687; -.
DR GeneCards; OR51A7; -.
DR HGNC; HGNC:15188; OR51A7.
DR HPA; ENSG00000176895; Not detected.
DR neXtProt; NX_Q8NH64; -.
DR OpenTargets; ENSG00000176895; -.
DR PharmGKB; PA32360; -.
DR VEuPathDB; HostDB:ENSG00000176895; -.
DR eggNOG; ENOG502RF9W; Eukaryota.
DR GeneTree; ENSGT01050000244899; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH64; -.
DR OMA; IMGNSTI; -.
DR OrthoDB; 947804at2759; -.
DR PhylomeDB; Q8NH64; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NH64; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119687; 8 hits in 669 CRISPR screens.
DR GeneWiki; OR51A7; -.
DR GenomeRNAi; 119687; -.
DR Pharos; Q8NH64; Tdark.
DR PRO; PR:Q8NH64; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH64; protein.
DR Bgee; ENSG00000176895; Expressed in fundus of stomach and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 51A7"
FT /id="PRO_0000150744"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 8
FT /note="E -> K (in dbSNP:rs11034596)"
FT /id="VAR_024140"
FT VARIANT 81
FT /note="M -> T (in dbSNP:rs7108225)"
FT /id="VAR_034315"
FT VARIANT 196
FT /note="V -> A (in dbSNP:rs7108654)"
FT /id="VAR_034316"
SQ SEQUENCE 312 AA; 35132 MW; 6D07CE27C104AACA CRC64;
MSVLNNSEVK LFLLIGIPGL EHAHIWFSIP ICLMYLLAIM GNCTILFIIK TEPSLHEPMY
YFLAMLAVSD MGLSLSSLPT MLRVFLFNAM GISPNACFAQ EFFIHGFTVM ESSVLLIMSL
DRFLAIHNPL RYSSILTSNR VAKMGLILAI RSILLVIPFP FTLRRLKYCQ KNLLSHSYCL
HQDTMKLACS DNKTNVIYGF FIALCTMLDL ALIVLSYVLI LKTILSIASL AERLKALNTC
VSHICAVLTF YVPIITLAAM HHFAKHKSPL VVILIADMFL LVPPLMNPIV YCVKTRQIWE
KILGKLLNVC GR
