O51B2_HUMAN
ID O51B2_HUMAN Reviewed; 312 AA.
AC Q9Y5P1; Q17R53; Q96RD4;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Olfactory receptor 51B2;
DE AltName: Full=Odorant receptor HOR5'beta3;
DE AltName: Full=Olfactory receptor 51B1;
GN Name=OR51B2; Synonyms=OR51B1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-120; PHE-134; SER-209
RP AND ARG-312.
RX PubMed=10220430; DOI=10.1073/pnas.96.9.5129;
RA Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M.,
RA Bender M.A., Felsenfeld G., Axel R., Groudine M.;
RT "Conservation of sequence and structure flanking the mouse and human beta-
RT globin loci: the beta-globin genes are embedded within an array of odorant
RT receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:5129-5134(1999).
RN [2]
RP ERRATUM OF PUBMED:10220430.
RA Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M.,
RA Bender M.A., Felsenfeld G., Axel R., Groudine M.;
RL Proc. Natl. Acad. Sci. U.S.A. 96:8307-8307(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-209 AND SER-283.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-283, AND VARIANTS ARG-120; PHE-134
RP AND SER-209.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6] {ECO:0007744|PDB:6LBG}
RP X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 303-311 IN COMPLEX WITH FEM1C,
RP AND UBIQUITINATION.
RX PubMed=33398168; DOI=10.1038/s41589-020-00704-3;
RA Chen X., Liao S., Makaros Y., Guo Q., Zhu Z., Krizelman R., Dahan K.,
RA Tu X., Yao X., Koren I., Xu C.;
RT "Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3
RT ligase.";
RL Nat. Chem. Biol. 17:254-262(2021).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: Ubiquitinated by the CRL2(FEM1A) and CRL2(FEM1C) complexes, which
CC recognize the -Lys-Xaa-Xaa-Arg C-degron at the C-terminus, leading to
CC its degradation. {ECO:0000269|PubMed:33398168}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51B2";
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DR EMBL; AF137396; AAD29425.2; -; Genomic_DNA.
DR EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117461; AAI17462.1; -; mRNA.
DR EMBL; AF399503; AAK94988.1; -; Genomic_DNA.
DR RefSeq; NP_149420.4; NM_033180.4.
DR PDB; 6LBG; X-ray; 2.51 A; A/B=303-311.
DR PDBsum; 6LBG; -.
DR AlphaFoldDB; Q9Y5P1; -.
DR SMR; Q9Y5P1; -.
DR BioGRID; 122650; 1.
DR STRING; 9606.ENSP00000327540; -.
DR GlyGen; Q9Y5P1; 1 site.
DR iPTMnet; Q9Y5P1; -.
DR PhosphoSitePlus; Q9Y5P1; -.
DR BioMuta; OR51B2; -.
DR DMDM; 296439490; -.
DR PaxDb; Q9Y5P1; -.
DR PeptideAtlas; Q9Y5P1; -.
DR PRIDE; Q9Y5P1; -.
DR ProteomicsDB; 86458; -.
DR Antibodypedia; 78942; 44 antibodies from 13 providers.
DR DNASU; 79345; -.
DR Ensembl; ENST00000624187.1; ENSP00000485407.1; ENSG00000279012.2.
DR GeneID; 79345; -.
DR KEGG; hsa:79345; -.
DR MANE-Select; ENST00000624187.1; ENSP00000485407.1; NM_033180.5; NP_149420.4.
DR UCSC; uc001mao.2; human.
DR CTD; 79345; -.
DR GeneCards; OR51B2; -.
DR HGNC; HGNC:14703; OR51B2.
DR HPA; ENSG00000279012; Not detected.
DR neXtProt; NX_Q9Y5P1; -.
DR PharmGKB; PA32364; -.
DR VEuPathDB; HostDB:ENSG00000279012; -.
DR eggNOG; ENOG502TAGS; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9Y5P1; -.
DR OMA; ILWVNHR; -.
DR OrthoDB; 988616at2759; -.
DR PhylomeDB; Q9Y5P1; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9Y5P1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79345; 6 hits in 673 CRISPR screens.
DR GeneWiki; OR51B2; -.
DR GenomeRNAi; 79345; -.
DR Pharos; Q9Y5P1; Tdark.
DR PRO; PR:Q9Y5P1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9Y5P1; protein.
DR Bgee; ENSG00000279012; Expressed in tibialis anterior and 6 other tissues.
DR ExpressionAtlas; Q9Y5P1; baseline and differential.
DR Genevisible; Q9Y5P1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Ubl conjugation.
FT CHAIN 1..312
FT /note="Olfactory receptor 51B2"
FT /id="PRO_0000150745"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 120
FT /note="C -> R (in dbSNP:rs7952293)"
FT /evidence="ECO:0000269|PubMed:10220430,
FT ECO:0000269|PubMed:12213199"
FT /id="VAR_063114"
FT VARIANT 134
FT /note="L -> F (in dbSNP:rs10837814)"
FT /evidence="ECO:0000269|PubMed:10220430,
FT ECO:0000269|PubMed:12213199"
FT /id="VAR_063115"
FT VARIANT 209
FT /note="C -> S (in dbSNP:rs7937237)"
FT /evidence="ECO:0000269|PubMed:10220430,
FT ECO:0000269|PubMed:12213199, ECO:0000269|PubMed:15489334"
FT /id="VAR_063116"
FT VARIANT 283
FT /note="P -> S (in dbSNP:rs11036815)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057576"
FT VARIANT 312
FT /note="S -> R (in dbSNP:rs11036814)"
FT /evidence="ECO:0000269|PubMed:10220430"
FT /id="VAR_063117"
SQ SEQUENCE 312 AA; 35373 MW; 47E1BA5852C36966 CRC64;
MWPNITAAPF LLTGFPGLEA AHHWISIPFF AVYVCILLGN GMLLYLIKHD HSLHEPMYYF
LTMLAGTDLM VTLTTMPTVM GILWVNHREI SSVGCFLQAY FIHSLSVVES GSLLAMAYDC
FIAIRNPLRY ASILTNTRVI ALGVGVFLRG FVSILPVILR LFSFSYCKSH VITRAFCLHQ
EIMRLACADI TFNRLYPVIL ISLTIFLDCL IILFSYILIL NTVIGIASGE ERAKALNTCI
SHISCVLIFY VTVMGLTFIY RFGKNVPEVV HIIMSYIYFL FPPLMNPVIY SIKTKQIQYG
IIRLLSKHRF SS
