O51B4_HUMAN
ID O51B4_HUMAN Reviewed; 310 AA.
AC Q9Y5P0; A7MAV5; Q6NTD7;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Olfactory receptor 51B4;
DE AltName: Full=Odorant receptor HOR5'beta1;
GN Name=OR51B4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-36.
RX PubMed=10220430; DOI=10.1073/pnas.96.9.5129;
RA Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M.,
RA Bender M.A., Felsenfeld G., Axel R., Groudine M.;
RT "Conservation of sequence and structure flanking the mouse and human beta-
RT globin loci: the beta-globin genes are embedded within an array of odorant
RT receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:5129-5134(1999).
RN [2]
RP ERRATUM OF PUBMED:10220430.
RA Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M.,
RA Bender M.A., Felsenfeld G., Axel R., Groudine M.;
RL Proc. Natl. Acad. Sci. U.S.A. 96:8307-8307(1999).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-36 AND THR-147.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51B4";
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DR EMBL; AF137396; AAD29426.2; -; Genomic_DNA.
DR EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069094; AAH69094.1; -; mRNA.
DR EMBL; BC148186; AAI48187.1; -; mRNA.
DR EMBL; BC153815; AAI53816.1; -; mRNA.
DR CCDS; CCDS7757.1; -.
DR RefSeq; NP_149419.2; NM_033179.2.
DR AlphaFoldDB; Q9Y5P0; -.
DR SMR; Q9Y5P0; -.
DR BioGRID; 122648; 1.
DR STRING; 9606.ENSP00000369573; -.
DR GlyGen; Q9Y5P0; 1 site.
DR iPTMnet; Q9Y5P0; -.
DR PhosphoSitePlus; Q9Y5P0; -.
DR BioMuta; OR51B4; -.
DR DMDM; 311033422; -.
DR PaxDb; Q9Y5P0; -.
DR PeptideAtlas; Q9Y5P0; -.
DR PRIDE; Q9Y5P0; -.
DR ProteomicsDB; 86457; -.
DR Antibodypedia; 55432; 8 antibodies from 8 providers.
DR DNASU; 79339; -.
DR Ensembl; ENST00000380224.2; ENSP00000369573.1; ENSG00000183251.4.
DR GeneID; 79339; -.
DR KEGG; hsa:79339; -.
DR MANE-Select; ENST00000380224.2; ENSP00000369573.1; NM_033179.2; NP_149419.2.
DR UCSC; uc010qza.3; human.
DR CTD; 79339; -.
DR GeneCards; OR51B4; -.
DR HGNC; HGNC:14708; OR51B4.
DR HPA; ENSG00000183251; Not detected.
DR neXtProt; NX_Q9Y5P0; -.
DR OpenTargets; ENSG00000183251; -.
DR PharmGKB; PA32366; -.
DR VEuPathDB; HostDB:ENSG00000183251; -.
DR eggNOG; ENOG502TAGS; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9Y5P0; -.
DR OMA; SEAIHHW; -.
DR OrthoDB; 1001156at2759; -.
DR PhylomeDB; Q9Y5P0; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9Y5P0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79339; 10 hits in 680 CRISPR screens.
DR GeneWiki; OR51B4; -.
DR GenomeRNAi; 79339; -.
DR Pharos; Q9Y5P0; Tdark.
DR PRO; PR:Q9Y5P0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9Y5P0; protein.
DR Bgee; ENSG00000183251; Expressed in right ovary and 21 other tissues.
DR Genevisible; Q9Y5P0; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 51B4"
FT /id="PRO_0000150746"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 36
FT /note="V -> I (in dbSNP:rs7118113)"
FT /evidence="ECO:0000269|PubMed:10220430,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_024141"
FT VARIANT 147
FT /note="M -> T (in dbSNP:rs10837771)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030348"
SQ SEQUENCE 310 AA; 34912 MW; 9B7586B751BEE5FA CRC64;
MWYNNSAGPF LLTGFLGSEA VHYRISMSFF VIYFSVLFGN GTLLVLIWND HSLHEPMYYF
LAMLADTDLG MTFTTMPTVL GVLLLDQREI AHAACFTQSF IHSLAIVESG ILLVLAYDCF
IAIRTPLRYN CILTNSRVMN IGLGVLMRGF MSILPIILSL YCYPYCGSRA LLHTFCLHQD
VIKLACADIT FNHIYPIIQT SLTVFLDALI IIFSYILILK TVMGIASGQE EAKSLNTCVS
HISCVLVFHI TVMGLSFIHR FGKHAPHVVP ITMSYVHFLF PPFVNPIIYS IKTKQIQRSI
IRLFSGQSRA
