O51B5_HUMAN
ID O51B5_HUMAN Reviewed; 312 AA.
AC Q9H339; B2RN59;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 51B5;
DE AltName: Full=Odorant receptor HOR5'beta5;
DE AltName: Full=Olfactory receptor OR11-37;
GN Name=OR51B5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-5.
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-5.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-5.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51B5";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF137396; AAG41683.1; -; Genomic_DNA.
DR EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68799.1; -; Genomic_DNA.
DR EMBL; BC136707; AAI36708.1; -; mRNA.
DR EMBL; BC136708; AAI36709.1; -; mRNA.
DR EMBL; BK004430; DAA04828.1; -; Genomic_DNA.
DR CCDS; CCDS31378.1; -.
DR RefSeq; NP_001005567.2; NM_001005567.2.
DR AlphaFoldDB; Q9H339; -.
DR SMR; Q9H339; -.
DR BioGRID; 129409; 2.
DR STRING; 9606.ENSP00000300773; -.
DR iPTMnet; Q9H339; -.
DR PhosphoSitePlus; Q9H339; -.
DR BioMuta; OR51B5; -.
DR DMDM; 296439245; -.
DR PaxDb; Q9H339; -.
DR PeptideAtlas; Q9H339; -.
DR PRIDE; Q9H339; -.
DR Antibodypedia; 78945; 66 antibodies from 19 providers.
DR DNASU; 282763; -.
DR Ensembl; ENST00000300773.3; ENSP00000300773.2; ENSG00000167355.8.
DR GeneID; 282763; -.
DR KEGG; hsa:282763; -.
DR MANE-Select; ENST00000300773.3; ENSP00000300773.2; NM_001395252.1; NP_001382181.1.
DR UCSC; uc057yhn.1; human.
DR CTD; 282763; -.
DR DisGeNET; 282763; -.
DR GeneCards; OR51B5; -.
DR HGNC; HGNC:19599; OR51B5.
DR HPA; ENSG00000167355; Not detected.
DR neXtProt; NX_Q9H339; -.
DR OpenTargets; ENSG00000167355; -.
DR PharmGKB; PA134907440; -.
DR VEuPathDB; HostDB:ENSG00000167355; -.
DR eggNOG; ENOG502TAGS; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H339; -.
DR OMA; QVPHIVH; -.
DR OrthoDB; 900491at2759; -.
DR PhylomeDB; Q9H339; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H339; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 282763; 7 hits in 617 CRISPR screens.
DR ChiTaRS; OR51B5; human.
DR GeneWiki; OR51B5; -.
DR GenomeRNAi; 282763; -.
DR Pharos; Q9H339; Tdark.
DR PRO; PR:Q9H339; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H339; protein.
DR Bgee; ENSG00000167355; Expressed in secondary oocyte and 86 other tissues.
DR ExpressionAtlas; Q9H339; baseline and differential.
DR Genevisible; Q9H339; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 51B5"
FT /id="PRO_0000150747"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 5
FT /note="G -> S (in dbSNP:rs11036913)"
FT /evidence="ECO:0000269|PubMed:11121057,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_053307"
FT VARIANT 78
FT /note="T -> K (in dbSNP:rs57273781)"
FT /id="VAR_062078"
FT VARIANT 88
FT /note="R -> G (in dbSNP:rs57900141)"
FT /id="VAR_062079"
FT VARIANT 102
FT /note="I -> T (in dbSNP:rs11036912)"
FT /id="VAR_053308"
FT VARIANT 154
FT /note="V -> I (in dbSNP:rs12273630)"
FT /id="VAR_053309"
FT VARIANT 160
FT /note="P -> L (in dbSNP:rs4910551)"
FT /id="VAR_053310"
FT VARIANT 220
FT /note="L -> F (in dbSNP:rs7120319)"
FT /id="VAR_053311"
SQ SEQUENCE 312 AA; 35241 MW; CC84A55EDED229C4 CRC64;
MSSSGSSHPF LLTGFPGLEE AHHWISVFFL FMYISILFGN GTLLLLIKED HNLHEPMYFF
LAMLAATDLG LALTTMPTVL GVLWLDHREI GSAACFSQAY FIHSLSFLES GILLAMAYDR
FIAICNPLRY TSVLTNTRVV KIGLGVLMRG FVSVVPPIRP LYFFLYCHSH VLSHAFCLHQ
DVIKLACADT TFNRLYPAVL VVFIFVLDYL IIFISYVLIL KTVLSIASRE ERAKALITCV
SHICCVLVFY VTVIGLSLIH RFGKQVPHIV HLIMSYAYFL FPPLMNPITY SVKTKQIQNA
ILHLFTTHRI GT
