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O51B6_HUMAN
ID   O51B6_HUMAN             Reviewed;         312 AA.
AC   Q9H340;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Olfactory receptor 51B6;
DE   AltName: Full=Odorant receptor HOR5'beta6;
GN   Name=OR51B6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-5; SER-40; THR-90;
RP   ILE-131; GLY-145; ALA-169; PHE-172; LEU-192 AND ARG-275.
RX   PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA   Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA   Felsenfeld G., Groudine M., Hardison R.;
RT   "Comparative structural and functional analysis of the olfactory receptor
RT   genes flanking the human and mouse beta-globin gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51B6";
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DR   EMBL; AF137396; AAG41682.1; -; Genomic_DNA.
DR   EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS31379.1; -.
DR   RefSeq; NP_001004750.1; NM_001004750.1.
DR   AlphaFoldDB; Q9H340; -.
DR   SMR; Q9H340; -.
DR   STRING; 9606.ENSP00000369568; -.
DR   GlyGen; Q9H340; 1 site.
DR   iPTMnet; Q9H340; -.
DR   PhosphoSitePlus; Q9H340; -.
DR   BioMuta; OR51B6; -.
DR   DMDM; 209572656; -.
DR   PaxDb; Q9H340; -.
DR   PeptideAtlas; Q9H340; -.
DR   PRIDE; Q9H340; -.
DR   Antibodypedia; 57755; 101 antibodies from 21 providers.
DR   DNASU; 390058; -.
DR   Ensembl; ENST00000380219.1; ENSP00000369568.1; ENSG00000176239.7.
DR   GeneID; 390058; -.
DR   KEGG; hsa:390058; -.
DR   MANE-Select; ENST00000380219.1; ENSP00000369568.1; NM_001004750.1; NP_001004750.1.
DR   UCSC; uc010qzb.2; human.
DR   CTD; 390058; -.
DR   DisGeNET; 390058; -.
DR   GeneCards; OR51B6; -.
DR   HGNC; HGNC:19600; OR51B6.
DR   HPA; ENSG00000176239; Not detected.
DR   neXtProt; NX_Q9H340; -.
DR   OpenTargets; ENSG00000176239; -.
DR   PharmGKB; PA134989095; -.
DR   VEuPathDB; HostDB:ENSG00000176239; -.
DR   eggNOG; ENOG502RTZQ; Eukaryota.
DR   GeneTree; ENSGT01050000244836; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9H340; -.
DR   OMA; NDHNLHE; -.
DR   OrthoDB; 877122at2759; -.
DR   PhylomeDB; Q9H340; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q9H340; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q9H340; -.
DR   BioGRID-ORCS; 390058; 9 hits in 667 CRISPR screens.
DR   GeneWiki; OR51B6; -.
DR   GenomeRNAi; 390058; -.
DR   Pharos; Q9H340; Tdark.
DR   PRO; PR:Q9H340; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H340; protein.
DR   Bgee; ENSG00000176239; Expressed in sural nerve and 2 other tissues.
DR   Genevisible; Q9H340; HS.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 51B6"
FT                   /id="PRO_0000150748"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         5
FT                   /note="K -> T (in dbSNP:rs4910755)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053312"
FT   VARIANT         40
FT                   /note="N -> S (in dbSNP:rs4910756)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053313"
FT   VARIANT         90
FT                   /note="I -> T (in dbSNP:rs7483122)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053314"
FT   VARIANT         123
FT                   /note="T -> A (in dbSNP:rs5006889)"
FT                   /id="VAR_053315"
FT   VARIANT         125
FT                   /note="R -> H (in dbSNP:rs7479477)"
FT                   /id="VAR_060035"
FT   VARIANT         126
FT                   /note="S -> N (in dbSNP:rs5006888)"
FT                   /id="VAR_060036"
FT   VARIANT         131
FT                   /note="T -> I (in dbSNP:rs5006887)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053316"
FT   VARIANT         145
FT                   /note="R -> G (in dbSNP:rs5006886)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053317"
FT   VARIANT         169
FT                   /note="S -> A (in dbSNP:rs5006885)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053318"
FT   VARIANT         172
FT                   /note="L -> F (in dbSNP:rs5006884)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053319"
FT   VARIANT         192
FT                   /note="F -> L (in dbSNP:rs5006883)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053320"
FT   VARIANT         254
FT                   /note="V -> L (in dbSNP:rs7106330)"
FT                   /id="VAR_053321"
FT   VARIANT         275
FT                   /note="S -> R (in dbSNP:rs5024042)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_053322"
FT   CONFLICT        123..126
FT                   /note="TIRS -> AIHN (in Ref. 1; AAG41682)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  35269 MW;  E7CCFDBD1FA50B45 CRC64;
     MGLNKSASTF QLTGFPGMEK AHHWIFIPLL AAYISILLGN GTLLFLIRND HNLHEPMYYF
     LAMLAATDLG VTLTTMPTVL GVLWLDHREI GHGACFSQAY FIHTLSVMES GVLLAMAYDC
     FITIRSPLRY TSILTNTQVM KIGVRVLTRA GLSIMPIVVR LHWFPYCRSH VLSHAFCLHQ
     DVIKLACADI TFNRLYPVVV LFAMVLLDFL IIFFSYILIL KTVMGIGSGG ERAKALNTCV
     SHICCILVFY VTVVCLTFIH RFGKHVPHVV HITMSYIHFL FPPFMNPFIY SIKTKQIQSG
     ILRLFSLPHS RA
 
 
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