ID   O51D1_HUMAN             Reviewed;         324 AA.
AC   Q8NGF3; B9EIK4;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Olfactory receptor 51D1;
DE   AltName: Full=Olfactory receptor OR11-14;
GN   Name=OR51D1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-89.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51D1";
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DR   EMBL; AB065855; BAC06073.1; -; Genomic_DNA.
DR   EMBL; BC140717; AAI40718.1; -; mRNA.
DR   EMBL; BK004370; DAA04768.1; -; Genomic_DNA.
DR   CCDS; CCDS31357.1; -.
DR   RefSeq; NP_001004751.1; NM_001004751.2.
DR   AlphaFoldDB; Q8NGF3; -.
DR   SMR; Q8NGF3; -.
DR   STRING; 9606.ENSP00000350222; -.
DR   PhosphoSitePlus; Q8NGF3; -.
DR   BioMuta; OR51D1; -.
DR   DMDM; 71153025; -.
DR   PaxDb; Q8NGF3; -.
DR   PeptideAtlas; Q8NGF3; -.
DR   PRIDE; Q8NGF3; -.
DR   Antibodypedia; 57488; 50 antibodies from 17 providers.
DR   DNASU; 390038; -.
DR   Ensembl; ENST00000357605.2; ENSP00000350222.2; ENSG00000197428.3.
DR   Ensembl; ENST00000641817.1; ENSP00000492986.1; ENSG00000197428.3.
DR   GeneID; 390038; -.
DR   KEGG; hsa:390038; -.
DR   MANE-Select; ENST00000641817.1; ENSP00000492986.1; NM_001004751.3; NP_001004751.1.
DR   UCSC; uc010qyk.2; human.
DR   CTD; 390038; -.
DR   DisGeNET; 390038; -.
DR   GeneCards; OR51D1; -.
DR   HGNC; HGNC:15193; OR51D1.
DR   HPA; ENSG00000197428; Not detected.
DR   neXtProt; NX_Q8NGF3; -.
DR   PharmGKB; PA32370; -.
DR   VEuPathDB; HostDB:ENSG00000197428; -.
DR   eggNOG; ENOG502R2IG; Eukaryota.
DR   GeneTree; ENSGT01050000244899; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NGF3; -.
DR   OMA; LGPNIHF; -.
DR   OrthoDB; 1159837at2759; -.
DR   PhylomeDB; Q8NGF3; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q8NGF3; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390038; 11 hits in 672 CRISPR screens.
DR   GeneWiki; OR51D1; -.
DR   GenomeRNAi; 390038; -.
DR   Pharos; Q8NGF3; Tdark.
DR   PRO; PR:Q8NGF3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGF3; protein.
DR   Bgee; ENSG00000197428; Expressed in stromal cell of endometrium and 1 other tissue.
DR   ExpressionAtlas; Q8NGF3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..324
FT                   /note="Olfactory receptor 51D1"
FT                   /id="PRO_0000150749"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..209
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..250
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..285
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        307..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        110..202
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         89
FT                   /note="I -> V (in dbSNP:rs905871)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_053323"
SQ   SEQUENCE   324 AA;  35839 MW;  52401F88565E3BD1 CRC64;
     MQKPQLLVPI IATSNGNLVH AAYFLLVGIP GLGPTIHFWL AFPLCFMYAL ATLGNLTIVL
     IIRVERRLHE PMYLFLAMLS TIDLVLSSIT MPKMASLFLM GIQEIEFNIC LAQMFLIHAL
     SAVESAVLLA MAFDRFVAIC HPLRHASVLT GCTVAKIGLS ALTRGFVFFF PLPFILKWLS
     YCQTHTVTHS FCLHQDIMKL SCTDTRVNVV YGLFIILSVM GVDSLFIGFS YILILWAVLE
     LSSRRAALKA FNTCISHLCA VLVFYVPLIG LSVVHRLGGP TSLLHVVMAN TYLLLPPVVN
     PLVYGAKTKE ICSRVLCMFS QGGK