O51E1_HUMAN
ID O51E1_HUMAN Reviewed; 317 AA.
AC Q8TCB6; A8KAM6; Q5S4P5; Q66X57; Q6IF93;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 51E1;
DE AltName: Full=D-GPCR;
DE AltName: Full=G-protein coupled receptor 164;
DE AltName: Full=Olfactory receptor 52A3;
DE AltName: Full=Prostate-overexpressed G protein-coupled receptor;
DE AltName: Full=Prostate-specific G protein-coupled receptor 2;
GN Name=OR51E1; Synonyms=GPR164, OR51E1P, OR52A3P, POGR, PSGR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Prostate;
RX PubMed=15313197; DOI=10.1016/j.bbrc.2004.07.106;
RA Weigle B., Fuessel S., Ebner R., Temme A., Schmitz M., Schwind S.,
RA Kiessling A., Rieger M.A., Meye A., Bachmann M., Wirth M.P., Rieber E.P.;
RT "D-GPCR: a novel putative G protein-coupled receptor overexpressed in
RT prostate cancer and prostate.";
RL Biochem. Biophys. Res. Commun. 322:239-249(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16206286; DOI=10.1002/ijc.21527;
RA Weng J., Wang J., Hu X., Wang F., Ittmann M., Liu M.;
RT "PSGR2, a novel G-protein coupled receptor, is overexpressed in human
RT prostate cancer.";
RL Int. J. Cancer 118:1471-1480(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [8]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8TCB6; Q8N5Z5: KCTD17; NbExp=3; IntAct=EBI-12141505, EBI-743960;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15313197};
CC Multi-pass membrane protein {ECO:0000269|PubMed:15313197}.
CC -!- TISSUE SPECIFICITY: Highly expressed in prostate. Very low levels may
CC be detected in some other tissues, such as placenta, skeletal muscle,
CC heart, ovary and testis. Up-regulated in prostate cancers.
CC {ECO:0000269|PubMed:15313197, ECO:0000269|PubMed:16206286}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAU07996.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=DAA04767.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51E1";
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DR EMBL; AY698056; AAU07996.1; ALT_INIT; mRNA.
DR EMBL; AB065787; BAC06006.1; -; Genomic_DNA.
DR EMBL; AY775731; AAV54110.1; -; mRNA.
DR EMBL; AK293091; BAF85780.1; -; mRNA.
DR EMBL; CH471064; EAW68832.1; -; Genomic_DNA.
DR EMBL; BC022401; AAH22401.1; -; mRNA.
DR EMBL; BK004369; DAA04767.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_689643.2; NM_152430.3.
DR AlphaFoldDB; Q8TCB6; -.
DR SMR; Q8TCB6; -.
DR BioGRID; 126808; 4.
DR IntAct; Q8TCB6; 1.
DR STRING; 9606.ENSP00000380155; -.
DR GlyGen; Q8TCB6; 2 sites.
DR BioMuta; OR51E1; -.
DR DMDM; 38372839; -.
DR MassIVE; Q8TCB6; -.
DR PaxDb; Q8TCB6; -.
DR PeptideAtlas; Q8TCB6; -.
DR PRIDE; Q8TCB6; -.
DR Antibodypedia; 23519; 186 antibodies from 27 providers.
DR DNASU; 143503; -.
DR Ensembl; ENST00000396952.6; ENSP00000380155.5; ENSG00000180785.10.
DR GeneID; 143503; -.
DR KEGG; hsa:143503; -.
DR UCSC; uc001lzi.5; human.
DR CTD; 143503; -.
DR DisGeNET; 143503; -.
DR GeneCards; OR51E1; -.
DR HGNC; HGNC:15194; OR51E1.
DR HPA; ENSG00000180785; Tissue enhanced (adipose tissue, placenta, prostate).
DR MIM; 611267; gene.
DR neXtProt; NX_Q8TCB6; -.
DR PharmGKB; PA32371; -.
DR VEuPathDB; HostDB:ENSG00000180785; -.
DR eggNOG; ENOG502QVRN; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8TCB6; -.
DR OMA; FHVTTHT; -.
DR OrthoDB; 1159837at2759; -.
DR PhylomeDB; Q8TCB6; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8TCB6; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8TCB6; -.
DR BioGRID-ORCS; 143503; 58 hits in 671 CRISPR screens.
DR ChiTaRS; OR51E1; human.
DR GeneWiki; OR51E1; -.
DR GenomeRNAi; 143503; -.
DR Pharos; Q8TCB6; Tbio.
DR PRO; PR:Q8TCB6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8TCB6; protein.
DR Bgee; ENSG00000180785; Expressed in secondary oocyte and 84 other tissues.
DR ExpressionAtlas; Q8TCB6; baseline and differential.
DR Genevisible; Q8TCB6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 51E1"
FT /id="PRO_0000150750"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 9
FT /note="S -> N (in dbSNP:rs17224476)"
FT /id="VAR_057577"
FT VARIANT 10
FT /note="S -> N (in dbSNP:rs17224476)"
FT /id="VAR_034317"
FT CONFLICT 305
FT /note="L -> P (in Ref. 1; AAU07996)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 35271 MW; 8C7293AA7FBCA95C CRC64;
MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI VRTEHSLHEP
MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL LQMFAIHSLS GMESTVLLAM
AFDRYVAICH PLRHATVLTL PRVTKIGVAA VVRGAALMAP LPVFIKQLPF CRSNILSHSY
CLHQDVMKLA CDDIRVNVVY GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG
TCVSHVCAVF IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI
RQRILRLFHV ATHASEP
