O51E2_RAT
ID O51E2_RAT Reviewed; 320 AA.
AC O88628;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Olfactory receptor 51E2;
DE AltName: Full=G-protein coupled receptor RA1c {ECO:0000303|PubMed:9932290};
DE AltName: Full=Olfactory receptor 59;
GN Name=Or51e2; Synonyms=Olr59, Psgr {ECO:0000303|PubMed:11707321};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9932290;
RA Raming K., Konzelmann S., Breer H.;
RT "Identification of a novel G-protein coupled receptor expressed in distinct
RT brain regions and a defined olfactory zone.";
RL Recept. Channels 6:141-151(1998).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=11707321; DOI=10.1016/s0378-1119(01)00709-0;
RA Yuan T.T., Toy P., McClary J.A., Lin R.J., Miyamoto N.G., Kretschmer P.J.;
RT "Cloning and genetic characterization of an evolutionarily conserved human
RT olfactory receptor that is differentially expressed across species.";
RL Gene 278:41-51(2001).
CC -!- FUNCTION: Olfactory receptor. The activity of this receptor is probably
CC mediated by G-proteins wich induce elevation of intracellular Ca(2+),
CC cAMP and activation of phosphorylation of the protein kinases PKA and
CC MAPK3/MAPK1. Activation of OR51E2 may affect melanocyte proliferation,
CC differentiation, and melanogenesis and may increase proliferation and
CC migration of primary retinal pigment epithelial (RPE) cells. Activated
CC by the short chain fatty acids (SCFA), acetate and propionate. In
CC response to SCFA, may positively regulate renin secretion and increase
CC blood pressure (By similarity). May also be activated by steroid
CC hormones and regulate cell proliferation (By similarity). Activated by
CC L-lactate in glomus cells (By similarity).
CC {ECO:0000250|UniProtKB:Q8VBV9, ECO:0000250|UniProtKB:Q9H255}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H255};
CC Multi-pass membrane protein {ECO:0000255}. Early endosome membrane
CC {ECO:0000250|UniProtKB:Q9H255}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in brain and liver. Expressed only in
CC some areas of the brain and in the olfactory epithelium.
CC {ECO:0000269|PubMed:11707321}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF079864; AAD12761.1; -; mRNA.
DR RefSeq; NP_775415.1; NM_173293.1.
DR AlphaFoldDB; O88628; -.
DR SMR; O88628; -.
DR STRING; 10116.ENSRNOP00000025097; -.
DR GlyGen; O88628; 1 site.
DR PaxDb; O88628; -.
DR GeneID; 170816; -.
DR KEGG; rno:170816; -.
DR UCSC; RGD:628858; rat.
DR CTD; 170816; -.
DR RGD; 628858; Olr59.
DR eggNOG; ENOG502QVRN; Eukaryota.
DR InParanoid; O88628; -.
DR OrthoDB; 1159837at2759; -.
DR PhylomeDB; O88628; -.
DR Reactome; R-RNO-381753; Olfactory Signaling Pathway.
DR PRO; PR:O88628; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043229; C:intracellular organelle; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0003707; F:nuclear steroid receptor activity; ISS:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; ISS:UniProtKB.
DR GO; GO:0038023; F:signaling receptor activity; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0071398; P:cellular response to fatty acid; ISS:UniProtKB.
DR GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
DR GO; GO:0097325; P:melanocyte proliferation; ISS:UniProtKB.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
DR GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:1900135; P:positive regulation of renin secretion into blood stream; ISS:UniProtKB.
DR GO; GO:0043401; P:steroid hormone mediated signaling pathway; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Endosome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 51E2"
FT /id="PRO_0000150752"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..178
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 320 AA; 35505 MW; E7FF78F5FFD5BF94 CRC64;
MSSCNFTHAT FMLIGIPGLE EAHFWFGFPL LSMYAVALFG NCIVVFIVRT ERSLHAPMYL
FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ITFDACLAQM FFIHALSAIE STILLAMAFD
RYVAICHPLR HAAVLNNTVT VQIGMVALVR GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH
QDVMKLAYTD TLPNVVYGLT AILLVMGVDV MFISLSYFLI IRAVLQLPSK SERAKAFGTC
VSHIGVVLAF YVPLIGLSVV HRFGNSLDPI VHVLMGDVYL LLPPVINPII YGAKTKQIRT
RVLAMFKISC DKDIEAGGNT
