O51F1_HUMAN
ID O51F1_HUMAN Reviewed; 319 AA.
AC A6NGY5;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Olfactory receptor 51F1;
GN Name=OR51F1; Synonyms=OR51F1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A single nucleotide deletion at position Arg-92 in the
CC gene coding for this protein is responsible for functional diversity
CC thus producing a pseudogene. The deletion is more frequent in African-
CC Americans than in non-Africans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51F1";
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DR EMBL; AC103710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NGY5; -.
DR SMR; A6NGY5; -.
DR STRING; 9606.ENSP00000345163; -.
DR GlyGen; A6NGY5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A6NGY5; -.
DR PhosphoSitePlus; A6NGY5; -.
DR BioMuta; OR51F1; -.
DR EPD; A6NGY5; -.
DR PaxDb; A6NGY5; -.
DR PeptideAtlas; A6NGY5; -.
DR PRIDE; A6NGY5; -.
DR Antibodypedia; 78531; 36 antibodies from 10 providers.
DR Ensembl; ENST00000624103.2; ENSP00000485387.2; ENSG00000280021.3.
DR MANE-Select; ENST00000624103.2; ENSP00000485387.2; NM_001004752.2; NP_001004752.2.
DR UCSC; uc057ygl.1; human.
DR GeneCards; OR51F1; -.
DR HGNC; HGNC:15196; OR51F1.
DR HPA; ENSG00000280021; Not detected.
DR neXtProt; NX_A6NGY5; -.
DR OpenTargets; ENSG00000280021; -.
DR VEuPathDB; HostDB:ENSG00000280021; -.
DR eggNOG; ENOG502SMHX; Eukaryota.
DR InParanoid; A6NGY5; -.
DR OMA; KPLYFCK; -.
DR PhylomeDB; A6NGY5; -.
DR PathwayCommons; A6NGY5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; A6NGY5; Tdark.
DR PRO; PR:A6NGY5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NGY5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 51F1"
FT /id="PRO_0000312489"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 106..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="T -> A (in dbSNP:rs17324812)"
FT /id="VAR_037506"
FT VARIANT 73
FT /note="F -> S (in dbSNP:rs11033801)"
FT /id="VAR_037507"
FT VARIANT 74
FT /note="R -> M (in dbSNP:rs11033800)"
FT /id="VAR_037508"
FT VARIANT 202
FT /note="R -> Q (in dbSNP:rs16938368)"
FT /id="VAR_057578"
FT VARIANT 232
FT /note="H -> R (in dbSNP:rs11033793)"
FT /id="VAR_037509"
FT VARIANT 233
FT /note="S -> F (in dbSNP:rs1030723)"
FT /id="VAR_060037"
FT VARIANT 258
FT /note="A -> V (in dbSNP:rs17324609)"
FT /id="VAR_057579"
FT VARIANT 301
FT /note="D -> Y (in dbSNP:rs1030726)"
FT /id="VAR_037510"
SQ SEQUENCE 319 AA; 35849 MW; EFDDA6C0393E449D CRC64;
MLQNQDTMEI LSNSTSKFPT FLLTGIPGLE SAHVWISIPF CCFYAIALSG NSVILFVIIT
QQSLHEPMYY FLFRLSATDL GLTVSSLSTT LGILWFEARE ISLYSCIVQM FFLHGFTFME
SGVLVATAFD RYVAICDPLR YTTILTNSRI IQMGLLMITR AIVLILPLLL LLKPLYFCRM
NALSHSYCYH PDVIQLACSD IRANSICGLI DLILTTGIDT PCIVLSYILI IHSVLRIASP
EEWHKVFSTC VSHVGAVAFF YIHMLSLSLV YRYGRSAPRV VHSVMANVYL LLPPVLNPII
DSVKTKQIRK AMLSLLLTK
