O51F2_HUMAN
ID O51F2_HUMAN Reviewed; 342 AA.
AC Q8NH61; Q6IFI1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Olfactory receptor 51F2;
DE AltName: Full=Olfactory receptor OR11-23;
GN Name=OR51F2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-13 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05776.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51F2";
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DR EMBL; AB065529; BAC05776.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC103710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68826.1; -; Genomic_DNA.
DR EMBL; BC136877; AAI36878.1; -; mRNA.
DR EMBL; BK004281; DAA04679.1; -; Genomic_DNA.
DR RefSeq; NP_001004753.1; NM_001004753.1.
DR AlphaFoldDB; Q8NH61; -.
DR SMR; Q8NH61; -.
DR BioGRID; 125652; 1.
DR IntAct; Q8NH61; 1.
DR STRING; 9606.ENSP00000323952; -.
DR GlyGen; Q8NH61; 1 site.
DR iPTMnet; Q8NH61; -.
DR PhosphoSitePlus; Q8NH61; -.
DR BioMuta; OR51F2; -.
DR DMDM; 223590112; -.
DR PaxDb; Q8NH61; -.
DR PRIDE; Q8NH61; -.
DR Antibodypedia; 57550; 49 antibodies from 15 providers.
DR DNASU; 119694; -.
DR Ensembl; ENST00000641672.1; ENSP00000493050.1; ENSG00000176925.8.
DR GeneID; 119694; -.
DR KEGG; hsa:119694; -.
DR UCSC; uc010qyn.2; human.
DR CTD; 119694; -.
DR DisGeNET; 119694; -.
DR GeneCards; OR51F2; -.
DR HGNC; HGNC:15197; OR51F2.
DR HPA; ENSG00000176925; Not detected.
DR neXtProt; NX_Q8NH61; -.
DR OpenTargets; ENSG00000176925; -.
DR PharmGKB; PA32375; -.
DR VEuPathDB; HostDB:ENSG00000176925; -.
DR eggNOG; ENOG502RF9W; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH61; -.
DR OrthoDB; 900491at2759; -.
DR PhylomeDB; Q8NH61; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NH61; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH61; -.
DR BioGRID-ORCS; 119694; 12 hits in 670 CRISPR screens.
DR GeneWiki; OR51F2; -.
DR GenomeRNAi; 119694; -.
DR Pharos; Q8NH61; Tdark.
DR PRO; PR:Q8NH61; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH61; protein.
DR ExpressionAtlas; Q8NH61; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..342
FT /note="Olfactory receptor 51F2"
FT /id="PRO_0000150753"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 342 AA; 38518 MW; CA3D91DB7B59EFB8 CRC64;
MTETSLSSQC FPMSVLNNTI AEPLIFLLMG IPGLKATQYW ISIPFCLLYV VAVSGNSMIL
FVVLCERSLH KPMYYFLSML SATDLSLSLC TLSTTLGVFW FEAREINLNA CIAQMFFLHG
FTFMESGVLL AMAFDRFVAI CYPLRYTTIL TNARIAKIGM SMLIRNVAVM LPVMLFVKRL
SFCSSMVLSH SYCYHVDLIQ LSCTDNRINS ILGLFALLST TGFDCPCILL SYILIIRSVL
SIASSEERRK AFNTCTSHIS AVSIFYLPLI SLSLVHRYGH SAPPFVHIIM ANVFLLIPPV
LNPIIYSVKI KQIQKAIIKV LIQKHSKSNH QLFLIRDKAI YE
