O51G1_HUMAN
ID O51G1_HUMAN Reviewed; 321 AA.
AC Q8NGK1; B9EGW8; Q6IFH6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 51G1;
DE AltName: Full=Olfactory receptor 51G3;
DE AltName: Full=Olfactory receptor OR11-29;
GN Name=OR51G1; Synonyms=OR51G3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-125.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51G1";
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DR EMBL; AB065793; BAC06012.1; -; Genomic_DNA.
DR EMBL; BC136852; AAI36853.1; -; mRNA.
DR EMBL; BC136861; AAI36862.1; -; mRNA.
DR EMBL; BK004286; DAA04684.1; -; Genomic_DNA.
DR RefSeq; NP_001005237.1; NM_001005237.1.
DR AlphaFoldDB; Q8NGK1; -.
DR SMR; Q8NGK1; -.
DR STRING; 9606.ENSP00000322546; -.
DR GlyGen; Q8NGK1; 1 site.
DR iPTMnet; Q8NGK1; -.
DR PhosphoSitePlus; Q8NGK1; -.
DR BioMuta; OR51G1; -.
DR DMDM; 38372713; -.
DR PaxDb; Q8NGK1; -.
DR PeptideAtlas; Q8NGK1; -.
DR PRIDE; Q8NGK1; -.
DR Antibodypedia; 78534; 96 antibodies from 21 providers.
DR DNASU; 79324; -.
DR Ensembl; ENST00000623849.1; ENSP00000485612.1; ENSG00000278870.2.
DR GeneID; 79324; -.
DR KEGG; hsa:79324; -.
DR MANE-Select; ENST00000623849.1; ENSP00000485612.1; NM_001005237.1; NP_001005237.1.
DR UCSC; uc010qyr.2; human.
DR CTD; 79324; -.
DR DisGeNET; 79324; -.
DR GeneCards; OR51G1; -.
DR HGNC; HGNC:14738; OR51G1.
DR HPA; ENSG00000278870; Not detected.
DR neXtProt; NX_Q8NGK1; -.
DR PharmGKB; PA32376; -.
DR VEuPathDB; HostDB:ENSG00000278870; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244899; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGK1; -.
DR OMA; FQYCRSH; -.
DR OrthoDB; 1159271at2759; -.
DR PhylomeDB; Q8NGK1; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGK1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79324; 11 hits in 664 CRISPR screens.
DR GeneWiki; OR51G1; -.
DR GenomeRNAi; 79324; -.
DR Pharos; Q8NGK1; Tdark.
DR PRO; PR:Q8NGK1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK1; protein.
DR ExpressionAtlas; Q8NGK1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 51G1"
FT /id="PRO_0000150754"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 114
FT /note="S -> L (in dbSNP:rs10836954)"
FT /id="VAR_053324"
FT VARIANT 124
FT /note="R -> H (in dbSNP:rs34742470)"
FT /id="VAR_053325"
FT VARIANT 125
FT /note="Y -> S (in dbSNP:rs1378739)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034318"
FT VARIANT 195
FT /note="I -> T (in dbSNP:rs12796015)"
FT /id="VAR_053326"
FT VARIANT 303
FT /note="Q -> H (in dbSNP:rs57920748)"
FT /id="VAR_062080"
SQ SEQUENCE 321 AA; 36290 MW; EDDEECD9FD1005C5 CRC64;
MTILLNSSLQ RATFFLTGFQ GLEGLHGWIS IPFCFIYLTV ILGNLTILHV ICTDATLHGP
MYYFLGMLAV TDLGLCLSTL PTVLGIFWFD TREIGIPACF TQLFFIHTLS SMESSVLLSM
SIDRYVAVCN PLHDSTVLTP ACIVKMGLSS VLRSALLILP LPFLLKRFQY CHSHVLAHAY
CLHLEIMKLA CSSIIVNHIY GLFVVACTVG VDSLLIFLSY ALILRTVLSI ASHQERLRAL
NTCVSHICAV LLFYIPMIGL SLVHRFGEHL PRVVHLFMSY VYLLVPPLMN PIIYSIKTKQ
IRQRIIKKFQ FIKSLRCFWK D
