O51G2_HUMAN
ID O51G2_HUMAN Reviewed; 314 AA.
AC Q8NGK0; Q6IFH7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 51G2;
DE AltName: Full=Olfactory receptor OR11-28;
GN Name=OR51G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51G2";
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DR EMBL; AB065794; BAC06013.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68821.1; -; Genomic_DNA.
DR EMBL; BC136830; AAI36831.1; -; mRNA.
DR EMBL; BC136831; AAI36832.1; -; mRNA.
DR EMBL; BK004285; DAA04683.1; -; Genomic_DNA.
DR CCDS; CCDS31365.1; -.
DR RefSeq; NP_001005238.1; NM_001005238.1.
DR AlphaFoldDB; Q8NGK0; -.
DR SMR; Q8NGK0; -.
DR STRING; 9606.ENSP00000322593; -.
DR GlyGen; Q8NGK0; 1 site.
DR iPTMnet; Q8NGK0; -.
DR PhosphoSitePlus; Q8NGK0; -.
DR BioMuta; OR51G2; -.
DR DMDM; 38372712; -.
DR PaxDb; Q8NGK0; -.
DR PRIDE; Q8NGK0; -.
DR Antibodypedia; 57565; 49 antibodies from 17 providers.
DR DNASU; 81282; -.
DR Ensembl; ENST00000641926.1; ENSP00000493323.1; ENSG00000176893.6.
DR GeneID; 81282; -.
DR KEGG; hsa:81282; -.
DR MANE-Select; ENST00000641926.1; ENSP00000493323.1; NM_001005238.2; NP_001005238.1.
DR UCSC; uc001lzr.1; human.
DR CTD; 81282; -.
DR DisGeNET; 81282; -.
DR GeneCards; OR51G2; -.
DR HGNC; HGNC:15198; OR51G2.
DR HPA; ENSG00000176893; Not detected.
DR neXtProt; NX_Q8NGK0; -.
DR OpenTargets; ENSG00000176893; -.
DR PharmGKB; PA32377; -.
DR VEuPathDB; HostDB:ENSG00000176893; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244899; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGK0; -.
DR OMA; GMFVIIS; -.
DR OrthoDB; 935241at2759; -.
DR PhylomeDB; Q8NGK0; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGK0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81282; 9 hits in 675 CRISPR screens.
DR GeneWiki; OR51G2; -.
DR GenomeRNAi; 81282; -.
DR Pharos; Q8NGK0; Tdark.
DR PRO; PR:Q8NGK0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK0; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 51G2"
FT /id="PRO_0000150755"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 94
FT /note="A -> E (in dbSNP:rs16907312)"
FT /id="VAR_053327"
FT VARIANT 96
FT /note="E -> Q (in dbSNP:rs12419598)"
FT /id="VAR_034319"
SQ SEQUENCE 314 AA; 35012 MW; 97DD37E1F38E976C CRC64;
MTLGSLGNSS SSVSATFLLS GIPGLERMHI WISIPLCFMY LVSIPGNCTI LFIIKTERSL
HEPMYLFLSM LALIDLGLSL CTLPTVLGIF WVGAREISHD ACFAQLFFIH CFSFLESSVL
LSMAFDRFVA ICHPLHYVSI LTNTVIGRIG LVSLGRSVAL IFPLPFMLKR FPYCGSPVLS
HSYCLHQEVM KLACADMKAN SIYGMFVIVS TVGIDSLLIL FSYALILRTV LSIASRAERF
KALNTCVSHI CAVLLFYTPM IGLSVIHRFG KQAPHLVQVV MGFMYLLFPP VMNPIVYSVK
TKQIRDRVTH AFCY
