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O51I1_HUMAN
ID   O51I1_HUMAN             Reviewed;         314 AA.
AC   Q9H343; B9EKW2; Q6IF33;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 161.
DE   RecName: Full=Olfactory receptor 51I1;
DE   AltName: Full=Odorant receptor HOR5'beta11;
DE   AltName: Full=Olfactory receptor OR11-39;
GN   Name=OR51I1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA   Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA   Felsenfeld G., Groudine M., Hardison R.;
RT   "Comparative structural and functional analysis of the olfactory receptor
RT   genes flanking the human and mouse beta-globin gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51I1";
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DR   EMBL; AF137396; AAG41679.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68794.1; -; Genomic_DNA.
DR   EMBL; BC151148; AAI51149.1; -; mRNA.
DR   EMBL; BK004429; DAA04827.1; -; Genomic_DNA.
DR   CCDS; CCDS31382.1; -.
DR   RefSeq; NP_001005288.1; NM_001005288.2.
DR   AlphaFoldDB; Q9H343; -.
DR   SMR; Q9H343; -.
DR   STRING; 9606.ENSP00000369559; -.
DR   BioMuta; OR51I1; -.
DR   DMDM; 14423835; -.
DR   PaxDb; Q9H343; -.
DR   PeptideAtlas; Q9H343; -.
DR   PRIDE; Q9H343; -.
DR   Antibodypedia; 55456; 87 antibodies from 20 providers.
DR   DNASU; 390063; -.
DR   Ensembl; ENST00000380211.1; ENSP00000369559.1; ENSG00000167359.8.
DR   GeneID; 390063; -.
DR   KEGG; hsa:390063; -.
DR   MANE-Select; ENST00000380211.1; ENSP00000369559.1; NM_001005288.3; NP_001005288.1.
DR   UCSC; uc010qze.3; human.
DR   CTD; 390063; -.
DR   DisGeNET; 390063; -.
DR   GeneCards; OR51I1; -.
DR   HGNC; HGNC:15200; OR51I1.
DR   HPA; ENSG00000167359; Not detected.
DR   neXtProt; NX_Q9H343; -.
DR   PharmGKB; PA32380; -.
DR   VEuPathDB; HostDB:ENSG00000167359; -.
DR   eggNOG; ENOG502RF9W; Eukaryota.
DR   GeneTree; ENSGT01050000244927; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9H343; -.
DR   OMA; TFCFNYH; -.
DR   OrthoDB; 875642at2759; -.
DR   PhylomeDB; Q9H343; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q9H343; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390063; 9 hits in 677 CRISPR screens.
DR   GeneWiki; OR51I1; -.
DR   GenomeRNAi; 390063; -.
DR   Pharos; Q9H343; Tdark.
DR   PRO; PR:Q9H343; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H343; protein.
DR   Bgee; ENSG00000167359; Expressed in right uterine tube and 5 other tissues.
DR   ExpressionAtlas; Q9H343; baseline and differential.
DR   Genevisible; Q9H343; HS.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 51I1"
FT                   /id="PRO_0000150757"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         124
FT                   /note="R -> H (in dbSNP:rs16930982)"
FT                   /id="VAR_053328"
FT   VARIANT         164
FT                   /note="V -> L (in dbSNP:rs11037445)"
FT                   /id="VAR_034320"
FT   VARIANT         252
FT                   /note="A -> S (in dbSNP:rs1498486)"
FT                   /id="VAR_024142"
SQ   SEQUENCE   314 AA;  35484 MW;  08B40AD79CB94911 CRC64;
     MLGLNGTPFQ PATLQLTGIP GIQTGLTWVA LIFCILYMIS IVGNLSILTL VFWEPALHQP
     MYYFLSMLAL NDLGVSFSTL PTVISTFCFN YNHVAFNACL VQMFFIHTFS FMESGILLAM
     SLDRFVAICY PLRYVTVLTH NRILAMGLGI LTKSFTTLFP FPFVVKRLPF CKGNVLHHSY
     CLHPDLMKVA CGDIHVNNIY GLLVIIFTYG MDSTFILLSY ALILRAMLVI ISQEQRLKAL
     NTCMSHICAV LAFYVPIIAV SMIHRFWKSA PPVVHVMMSN VYLFVPPMLN PIIYSVKTKE
     IRKGILKFFH KSQA
 
 
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