O51I2_HUMAN
ID O51I2_HUMAN Reviewed; 312 AA.
AC Q9H344; B9EIL6; Q6IF81;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Olfactory receptor 51I2;
DE AltName: Full=Odorant receptor HOR5'beta12;
DE AltName: Full=Olfactory receptor OR11-38;
GN Name=OR51I2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-263.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR51I2/term:OR51I2/type:keyword";
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DR EMBL; AF137396; AAG41678.1; -; Genomic_DNA.
DR EMBL; BC140730; AAI40731.1; -; mRNA.
DR EMBL; BK004381; DAA04779.1; -; Genomic_DNA.
DR CCDS; CCDS31383.1; -.
DR RefSeq; NP_001004754.1; NM_001004754.2.
DR AlphaFoldDB; Q9H344; -.
DR SMR; Q9H344; -.
DR STRING; 9606.ENSP00000341987; -.
DR GlyGen; Q9H344; 1 site.
DR iPTMnet; Q9H344; -.
DR PhosphoSitePlus; Q9H344; -.
DR BioMuta; OR51I2; -.
DR DMDM; 14423836; -.
DR PaxDb; Q9H344; -.
DR PeptideAtlas; Q9H344; -.
DR PRIDE; Q9H344; -.
DR Antibodypedia; 57765; 64 antibodies from 19 providers.
DR DNASU; 390064; -.
DR Ensembl; ENST00000641930.1; ENSP00000493016.1; ENSG00000187918.6.
DR GeneID; 390064; -.
DR KEGG; hsa:390064; -.
DR MANE-Select; ENST00000641930.1; ENSP00000493016.1; NM_001004754.3; NP_001004754.1.
DR UCSC; uc010qzf.3; human.
DR CTD; 390064; -.
DR DisGeNET; 390064; -.
DR GeneCards; OR51I2; -.
DR HGNC; HGNC:15201; OR51I2.
DR HPA; ENSG00000187918; Not detected.
DR neXtProt; NX_Q9H344; -.
DR OpenTargets; ENSG00000187918; -.
DR PharmGKB; PA32381; -.
DR VEuPathDB; HostDB:ENSG00000187918; -.
DR eggNOG; ENOG502RTZR; Eukaryota.
DR GeneTree; ENSGT01050000244927; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H344; -.
DR OMA; TFCLDAR; -.
DR OrthoDB; 954086at2759; -.
DR PhylomeDB; Q9H344; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H344; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390064; 22 hits in 667 CRISPR screens.
DR GeneWiki; OR51I2; -.
DR GenomeRNAi; 390064; -.
DR Pharos; Q9H344; Tdark.
DR PRO; PR:Q9H344; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H344; protein.
DR Bgee; ENSG00000187918; Expressed in tibialis anterior and 3 other tissues.
DR ExpressionAtlas; Q9H344; baseline and differential.
DR Genevisible; Q9H344; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 51I2"
FT /id="PRO_0000150758"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 122
FT /note="R -> C (in dbSNP:rs10450603)"
FT /id="VAR_034321"
FT VARIANT 134
FT /note="T -> A (in dbSNP:rs12577167)"
FT /id="VAR_034322"
FT VARIANT 151
FT /note="R -> P (in dbSNP:rs16931292)"
FT /id="VAR_034323"
FT VARIANT 263
FT /note="R -> H (in dbSNP:rs11037502)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024143"
SQ SEQUENCE 312 AA; 35002 MW; F17CD16C95FD1AF6 CRC64;
MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR VEPSLHEPMY
YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ MFLIHFFSMM ESGILLAMSF
DRYVAICDPL RYATVLTTEV IAAMGLGAAA RSFITLFPLP FLIKRLPICR SNVLSHSYCL
HPDMMRLACA DISINSIYGL FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT
CVSHILAVLA FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR
RAIFRMFHHI KI
