O51J1_HUMAN
ID O51J1_HUMAN Reviewed; 316 AA.
AC Q9H342;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Olfactory receptor 51J1;
DE AltName: Full=Odorant receptor HOR5'beta8;
DE AltName: Full=Olfactory receptor 51J2;
GN Name=OR51J1; Synonyms=OR51J1P, OR51J2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP POLYMORPHISM, AND VARIANT TYR-100.
RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284;
RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W.,
RA Lancet D.;
RT "Genetic elucidation of human hyperosmia to isovaleric acid.";
RL PLoS Biol. 5:2462-2468(2007).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A nonsynonymous SNP at position Cys-100, a highly
CC conserved amino-acid, in the gene coding for this protein is
CC responsible for functional diversity.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51J1";
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DR EMBL; AF137396; AAG41680.1; -; Genomic_DNA.
DR EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001335153.1; NM_001348224.1.
DR AlphaFoldDB; Q9H342; -.
DR SMR; Q9H342; -.
DR STRING; 9606.ENSP00000332473; -.
DR GlyGen; Q9H342; 1 site.
DR BioMuta; OR51J1; -.
DR DMDM; 190359996; -.
DR PaxDb; Q9H342; -.
DR PRIDE; Q9H342; -.
DR DNASU; 79470; -.
DR GeneID; 79470; -.
DR KEGG; hsa:79470; -.
DR UCSC; uc057yhp.1; human.
DR CTD; 79470; -.
DR GeneCards; OR51J1; -.
DR HGNC; HGNC:14856; OR51J1.
DR neXtProt; NX_Q9H342; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H342; -.
DR OrthoDB; 1179332at2759; -.
DR PhylomeDB; Q9H342; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H342; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79470; 2 hits in 110 CRISPR screens.
DR Pharos; Q9H342; Tdark.
DR PRO; PR:Q9H342; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9H342; protein.
DR Genevisible; Q9H342; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 51J1"
FT /id="PRO_0000341578"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 100
FT /note="C -> Y (in dbSNP:rs1909261)"
FT /evidence="ECO:0000269|PubMed:17973576"
FT /id="VAR_044085"
FT CONFLICT 75
FT /note="R -> H (in Ref. 1; AAG41680)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 34838 MW; C7EF56E30BAFF40F CRC64;
MKISNNSLGF LPTTFILVGI PGLESEHLWI SVPFSLIYII IFLGNGIILH VIRTDIALHQ
PMYLFLAMLA LAEVRVSAST LPTVLGIFLF GNTEISLEAC LFPDVLHPFF IHDGASCAAG
HVFGPLYSHL QPTELHSYPD TAQGLWHRSY YRTEKHYAHG SVAHSLMASA LLWPQCPLTF
LLSAPQSYLS CGNISVNNIY GIFIVTSTFG LDSLLIVISY GLILHTVLGI ATGEGRKKAL
NTCGSHVCAV LAYYVPMIGL SIVHRLGHRV SPLLQAMMAN AYLFFPPVVN PIVYSIKTKE
IHGAIVRMLL EKRRRV
