ID   O51L1_HUMAN             Reviewed;         315 AA.
AC   Q8NGJ5; Q6IFE5;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Olfactory receptor 51L1;
DE   AltName: Full=Olfactory receptor OR11-31;
GN   Name=OR51L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51L1";
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DR   EMBL; AB065799; BAC06018.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68816.1; -; Genomic_DNA.
DR   EMBL; BK004317; DAA04715.1; -; Genomic_DNA.
DR   CCDS; CCDS31369.1; -.
DR   RefSeq; NP_001004755.1; NM_001004755.1.
DR   AlphaFoldDB; Q8NGJ5; -.
DR   SMR; Q8NGJ5; -.
DR   BioGRID; 125649; 12.
DR   STRING; 9606.ENSP00000322156; -.
DR   GlyGen; Q8NGJ5; 1 site.
DR   BioMuta; OR51L1; -.
DR   DMDM; 38372707; -.
DR   PaxDb; Q8NGJ5; -.
DR   PRIDE; Q8NGJ5; -.
DR   ProteomicsDB; 73531; -.
DR   Antibodypedia; 65297; 65 antibodies from 18 providers.
DR   DNASU; 119682; -.
DR   Ensembl; ENST00000641819.1; ENSP00000493015.1; ENSG00000176798.3.
DR   GeneID; 119682; -.
DR   KEGG; hsa:119682; -.
DR   MANE-Select; ENST00000641819.1; ENSP00000493015.1; NM_001004755.2; NP_001004755.1.
DR   UCSC; uc010qyu.2; human.
DR   CTD; 119682; -.
DR   DisGeNET; 119682; -.
DR   GeneCards; OR51L1; -.
DR   HGNC; HGNC:14759; OR51L1.
DR   HPA; ENSG00000176798; Not detected.
DR   neXtProt; NX_Q8NGJ5; -.
DR   OpenTargets; ENSG00000176798; -.
DR   PharmGKB; PA32384; -.
DR   VEuPathDB; HostDB:ENSG00000176798; -.
DR   eggNOG; ENOG502SI1B; Eukaryota.
DR   GeneTree; ENSGT01050000244927; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NGJ5; -.
DR   OMA; SVIWIES; -.
DR   OrthoDB; 1004547at2759; -.
DR   PhylomeDB; Q8NGJ5; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q8NGJ5; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 119682; 10 hits in 672 CRISPR screens.
DR   GeneWiki; OR51L1; -.
DR   GenomeRNAi; 119682; -.
DR   Pharos; Q8NGJ5; Tdark.
DR   PRO; PR:Q8NGJ5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGJ5; protein.
DR   Bgee; ENSG00000176798; Expressed in colonic epithelium and 1 other tissue.
DR   ExpressionAtlas; Q8NGJ5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 51L1"
FT                   /id="PRO_0000150759"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         196
FT                   /note="T -> I (in dbSNP:rs10768448)"
FT                   /id="VAR_034324"
FT   VARIANT         207
FT                   /note="A -> V (in dbSNP:rs10768450)"
FT                   /id="VAR_034325"
SQ   SEQUENCE   315 AA;  35369 MW;  2F85D0A03440813D CRC64;
     MGDWNNSDAV EPIFILRGFP GLEYVHSWLS ILFCLAYLVA FMGNVTILSV IWIESSLHQP
     MYYFISILAV NDLGMSLSTL PTMLAVLWLD APEIQASACY AQLFFIHTFT FLESSVLLAM
     AFDRFVAICH PLHYPTILTN SVIGKIGLAC LLRSLGVVLP TPLLLRHYHY CHGNALSHAF
     CLHQDVLRLS CTDARTNSIY GLCVVIATLG VDSIFILLSY VLILNTVLDI ASREEQLKAL
     NTCVSHICVV LIFFVPVIGV SMVHRFGKHL SPIVHILMAD IYLLLPPVLN PIVYSVRTKQ
     IRLGILHKFV LRRRF