O51M1_HUMAN
ID O51M1_HUMAN Reviewed; 326 AA.
AC Q9H341; Q6IF80;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 4.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Olfactory receptor 51M1;
DE AltName: Full=Odorant receptor HOR5'beta7;
DE AltName: Full=Olfactory receptor OR11-40;
GN Name=OR51M1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-102; PHE-135; THR-204;
RP HIS-256; ARG-257 AND LEU-318.
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP IDENTIFICATION, AND VARIANTS GLN-102; PHE-135; THR-204; HIS-256 AND
RP LEU-318.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51M1";
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DR EMBL; AF137396; AAG41681.1; -; Genomic_DNA.
DR EMBL; BK004382; DAA04780.1; -; Genomic_DNA.
DR CCDS; CCDS53596.1; -.
DR RefSeq; NP_001004756.2; NM_001004756.2.
DR AlphaFoldDB; Q9H341; -.
DR SMR; Q9H341; -.
DR BioGRID; 133378; 2.
DR IntAct; Q9H341; 1.
DR STRING; 9606.ENSP00000333196; -.
DR GlyGen; Q9H341; 1 site.
DR iPTMnet; Q9H341; -.
DR PhosphoSitePlus; Q9H341; -.
DR BioMuta; OR51M1; -.
DR DMDM; 84028232; -.
DR PaxDb; Q9H341; -.
DR PeptideAtlas; Q9H341; -.
DR PRIDE; Q9H341; -.
DR Antibodypedia; 66884; 78 antibodies from 20 providers.
DR DNASU; 390059; -.
DR Ensembl; ENST00000328611.5; ENSP00000333196.3; ENSG00000184698.5.
DR Ensembl; ENST00000642046.1; ENSP00000493005.1; ENSG00000184698.5.
DR GeneID; 390059; -.
DR KEGG; hsa:390059; -.
DR MANE-Select; ENST00000642046.1; ENSP00000493005.1; NM_001004756.3; NP_001004756.2.
DR UCSC; uc010qzc.3; human.
DR CTD; 390059; -.
DR DisGeNET; 390059; -.
DR GeneCards; OR51M1; -.
DR HGNC; HGNC:14847; OR51M1.
DR HPA; ENSG00000184698; Not detected.
DR neXtProt; NX_Q9H341; -.
DR VEuPathDB; HostDB:ENSG00000184698; -.
DR eggNOG; ENOG502SMGT; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H341; -.
DR OMA; EHWIFIP; -.
DR OrthoDB; 872354at2759; -.
DR PhylomeDB; Q9H341; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H341; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9H341; -.
DR BioGRID-ORCS; 390059; 9 hits in 664 CRISPR screens.
DR GeneWiki; OR51M1; -.
DR GenomeRNAi; 390059; -.
DR Pharos; Q9H341; Tdark.
DR PRO; PR:Q9H341; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H341; protein.
DR Bgee; ENSG00000184698; Expressed in apex of heart.
DR Genevisible; Q9H341; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 51M1"
FT /id="PRO_0000150760"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 102
FT /note="H -> Q (in dbSNP:rs1498467)"
FT /evidence="ECO:0000269|PubMed:11121057,
FT ECO:0000269|PubMed:14983052"
FT /id="VAR_070593"
FT VARIANT 135
FT /note="L -> F (in dbSNP:rs1498468)"
FT /evidence="ECO:0000269|PubMed:11121057,
FT ECO:0000269|PubMed:14983052"
FT /id="VAR_070594"
FT VARIANT 204
FT /note="I -> T (in dbSNP:rs1498469)"
FT /evidence="ECO:0000269|PubMed:11121057,
FT ECO:0000269|PubMed:14983052"
FT /id="VAR_070595"
FT VARIANT 256
FT /note="P -> H (in dbSNP:rs9783355)"
FT /evidence="ECO:0000269|PubMed:11121057,
FT ECO:0000269|PubMed:14983052"
FT /id="VAR_070596"
FT VARIANT 257
FT /note="L -> R (in dbSNP:rs2736531)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_070597"
FT VARIANT 318
FT /note="F -> L (in dbSNP:rs10768907)"
FT /evidence="ECO:0000269|PubMed:11121057,
FT ECO:0000269|PubMed:14983052"
FT /id="VAR_070598"
SQ SEQUENCE 326 AA; 36669 MW; 6082F43BF5A2D417 CRC64;
MSVQYSLSPQ FMLLSNITQF SPIFYLTSFP GLEGIKHWIF IPFFFMYMVA ISGNCFILII
IKTNPRLHTP MYYLLSLLAL TDLGLCVSTL PTTMGIFWFN SHSIYFGACQ IQMFCIHSFS
FMESSVLLMM SFDRLVAICH PLRYSVIITG QQVVRAGLIV IFRGPVATIP IVLLLKAFPY
CGSVVLSHSF CLHQEVIQLA CTDITFNNLY GLMVVVFTVM LDLVLIALSY GLILHTVAGL
ASQEEQRRAF QTCTAPLCAV LVFFVPMMGL SLVHRFGKHA PPAIHLLMAN VYLFVPPMLN
PIIYSIKTKE IHRAIIKFLG LKKASK
