O51Q1_HUMAN
ID O51Q1_HUMAN Reviewed; 317 AA.
AC Q8NH59; B2RNN1;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 51Q1;
GN Name=OR51Q1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-303, AND VARIANTS ILE-146 AND
RP HIS-178.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP POLYMORPHISM.
RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284;
RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W.,
RA Lancet D.;
RT "Genetic elucidation of human hyperosmia to isovaleric acid.";
RL PLoS Biol. 5:2462-2468(2007).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon at position Arg-236 in the gene coding for
CC this protein is responsible for functional diversity thus producing a
CC pseudogene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51Q1";
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DR EMBL; AC087380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136999; AAI37000.1; -; mRNA.
DR EMBL; AB065531; BAC05778.1; -; Genomic_DNA.
DR CCDS; CCDS31381.1; -.
DR RefSeq; NP_001004757.1; NM_001004757.2.
DR AlphaFoldDB; Q8NH59; -.
DR SMR; Q8NH59; -.
DR BioGRID; 133379; 2.
DR STRING; 9606.ENSP00000300778; -.
DR GlyGen; Q8NH59; 1 site.
DR iPTMnet; Q8NH59; -.
DR PhosphoSitePlus; Q8NH59; -.
DR BioMuta; OR51Q1; -.
DR DMDM; 38258182; -.
DR MassIVE; Q8NH59; -.
DR PaxDb; Q8NH59; -.
DR PeptideAtlas; Q8NH59; -.
DR PRIDE; Q8NH59; -.
DR Antibodypedia; 49518; 91 antibodies from 23 providers.
DR DNASU; 390061; -.
DR Ensembl; ENST00000300778.4; ENSP00000300778.4; ENSG00000167360.6.
DR GeneID; 390061; -.
DR KEGG; hsa:390061; -.
DR MANE-Select; ENST00000300778.4; ENSP00000300778.4; NM_001004757.2; NP_001004757.1.
DR UCSC; uc010qzd.2; human.
DR CTD; 390061; -.
DR DisGeNET; 390061; -.
DR GeneCards; OR51Q1; -.
DR HGNC; HGNC:14851; OR51Q1.
DR HPA; ENSG00000167360; Not detected.
DR neXtProt; NX_Q8NH59; -.
DR PharmGKB; PA32388; -.
DR VEuPathDB; HostDB:ENSG00000167360; -.
DR eggNOG; ENOG502SMGT; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH59; -.
DR OMA; IRLNSWY; -.
DR OrthoDB; 1017260at2759; -.
DR PhylomeDB; Q8NH59; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NH59; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390061; 8 hits in 670 CRISPR screens.
DR GeneWiki; OR51Q1; -.
DR GenomeRNAi; 390061; -.
DR Pharos; Q8NH59; Tdark.
DR PRO; PR:Q8NH59; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH59; protein.
DR Bgee; ENSG00000167360; Expressed in sural nerve and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 51Q1"
FT /id="PRO_0000150761"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 146
FT /note="T -> I (in dbSNP:rs10838092)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_034326"
FT VARIANT 153
FT /note="C -> R (in dbSNP:rs10838093)"
FT /id="VAR_034327"
FT VARIANT 155
FT /note="V -> I (in dbSNP:rs10838094)"
FT /id="VAR_053329"
FT VARIANT 178
FT /note="R -> H (in dbSNP:rs10838095)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_034328"
FT VARIANT 211
FT /note="V -> M (in dbSNP:rs2736586)"
FT /id="VAR_024144"
FT VARIANT 308
FT /note="F -> S (in dbSNP:rs2647573)"
FT /id="VAR_053330"
FT CONFLICT 153..155
FT /note="CCV -> RCI (in Ref. 3; BAC05778)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 35747 MW; E8E0E761B05848EB CRC64;
MSQVTNTTQE GIYFILTDIP GFEASHIWIS IPVCCLYTIS IMGNTTILTV IRTEPSVHQR
MYLFLSMLAL TDLGLTLTTL PTVMQLLWFN VRRISSEACF AQFFFLHGFS FMESSVLLAM
SVDCYVAICC PLHYASILTN EVIGRTGLAI ICCCVLAVLP SLFLLKRLPF CHSHLLSRSY
CLHQDMIRLV CADIRLNSWY GFALALLIII VDPLLIVISY TLILKNILGT ATWAERLRAL
NNCLSHILAV LVLYIPMVGV SMTHRFAKHA SPLVHVIMAN IYLLAPPVMN PIIYSVKNKQ
IQWGMLNFLS LKNMHSR
