O51S1_HUMAN
ID O51S1_HUMAN Reviewed; 323 AA.
AC Q8NGJ8; B9EGZ1; Q6IFI2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 51S1;
DE AltName: Full=Olfactory receptor OR11-24;
GN Name=OR51S1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51S1";
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DR EMBL; AB065796; BAC06015.1; -; Genomic_DNA.
DR EMBL; BC136932; AAI36933.1; -; mRNA.
DR EMBL; BC136934; AAI36935.1; -; mRNA.
DR EMBL; BK004280; DAA04678.1; -; Genomic_DNA.
DR CCDS; CCDS31362.1; -.
DR RefSeq; NP_001004758.1; NM_001004758.1.
DR AlphaFoldDB; Q8NGJ8; -.
DR SMR; Q8NGJ8; -.
DR STRING; 9606.ENSP00000322754; -.
DR GlyGen; Q8NGJ8; 1 site.
DR BioMuta; OR51S1; -.
DR DMDM; 38372710; -.
DR MassIVE; Q8NGJ8; -.
DR PaxDb; Q8NGJ8; -.
DR PeptideAtlas; Q8NGJ8; -.
DR PRIDE; Q8NGJ8; -.
DR Antibodypedia; 57560; 101 antibodies from 20 providers.
DR DNASU; 119692; -.
DR Ensembl; ENST00000322101.5; ENSP00000322754.2; ENSG00000176922.5.
DR GeneID; 119692; -.
DR KEGG; hsa:119692; -.
DR MANE-Select; ENST00000322101.5; ENSP00000322754.2; NM_001004758.1; NP_001004758.1.
DR UCSC; uc010qyo.2; human.
DR CTD; 119692; -.
DR DisGeNET; 119692; -.
DR GeneCards; OR51S1; -.
DR HGNC; HGNC:15204; OR51S1.
DR HPA; ENSG00000176922; Not detected.
DR neXtProt; NX_Q8NGJ8; -.
DR OpenTargets; ENSG00000176922; -.
DR PharmGKB; PA32390; -.
DR VEuPathDB; HostDB:ENSG00000176922; -.
DR eggNOG; ENOG502RF9W; Eukaryota.
DR GeneTree; ENSGT01050000244927; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ8; -.
DR OMA; ESREDRW; -.
DR OrthoDB; 900491at2759; -.
DR PhylomeDB; Q8NGJ8; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGJ8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119692; 11 hits in 682 CRISPR screens.
DR GeneWiki; OR51S1; -.
DR GenomeRNAi; 119692; -.
DR Pharos; Q8NGJ8; Tdark.
DR PRO; PR:Q8NGJ8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ8; protein.
DR ExpressionAtlas; Q8NGJ8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 51S1"
FT /id="PRO_0000150762"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 57
FT /note="I -> N (in dbSNP:rs12417164)"
FT /id="VAR_034329"
FT VARIANT 60
FT /note="Q -> E (in dbSNP:rs11602499)"
FT /id="VAR_034330"
FT VARIANT 178
FT /note="L -> R (in dbSNP:rs7117260)"
FT /id="VAR_024145"
FT VARIANT 264
FT /note="L -> F (in dbSNP:rs12361955)"
FT /id="VAR_053331"
SQ SEQUENCE 323 AA; 35313 MW; 366318DDE5CE6D73 CRC64;
MSTLPTQIAP NSSTSMAPTF LLVGMPGLSG APSWWTLPLI AVYLLSALGN GTILWIIALQ
PALHRPMHFF LFLLSVSDIG LVTALMPTLL GIALAGAHTV PASACLLQMV FIHVFSVMES
SVLLAMSIDR ALAICRPLHY PALLTNGVIS KISLAISFRC LGLHLPLPFL LAYMPYCLPQ
VLTHSYCLHP DVARLACPEA WGAAYSLFVV LSAMGLDPLL IFFSYGLIGK VLQGVESRED
RWKAGQTCAA HLSAVLLFYI PMILLALINH PELPITQHTH TLLSYVHFLL PPLINPILYS
VKMKEIRKRI LNRLQPRKVG GAQ
