O51T1_HUMAN
ID O51T1_HUMAN Reviewed; 327 AA.
AC Q8NGJ9; Q6IFH9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 51T1;
DE AltName: Full=Olfactory receptor OR11-26;
GN Name=OR51T1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04681.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51T1";
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DR EMBL; AB065795; BAC06014.1; -; Genomic_DNA.
DR EMBL; AC011711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004283; DAA04681.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31363.1; -.
DR RefSeq; NP_001004759.1; NM_001004759.1.
DR AlphaFoldDB; Q8NGJ9; -.
DR SMR; Q8NGJ9; -.
DR STRING; 9606.ENSP00000369738; -.
DR GlyGen; Q8NGJ9; 2 sites.
DR BioMuta; OR51T1; -.
DR DMDM; 38372711; -.
DR PaxDb; Q8NGJ9; -.
DR PeptideAtlas; Q8NGJ9; -.
DR PRIDE; Q8NGJ9; -.
DR ProteomicsDB; 73535; -.
DR Antibodypedia; 62714; 101 antibodies from 23 providers.
DR DNASU; 401665; -.
DR Ensembl; ENST00000322049.1; ENSP00000322679.1; ENSG00000176900.2.
DR GeneID; 401665; -.
DR KEGG; hsa:401665; -.
DR MANE-Select; ENST00000322049.1; ENSP00000322679.1; NM_001004759.3; NP_001004759.2.
DR UCSC; uc010qyp.2; human.
DR CTD; 401665; -.
DR GeneCards; OR51T1; -.
DR HGNC; HGNC:15205; OR51T1.
DR HPA; ENSG00000176900; Not detected.
DR neXtProt; NX_Q8NGJ9; -.
DR OpenTargets; ENSG00000176900; -.
DR VEuPathDB; HostDB:ENSG00000176900; -.
DR eggNOG; ENOG502RU2C; Eukaryota.
DR GeneTree; ENSGT01050000244836; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ9; -.
DR OrthoDB; 900491at2759; -.
DR PhylomeDB; Q8NGJ9; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGJ9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 401665; 10 hits in 674 CRISPR screens.
DR GeneWiki; OR51T1; -.
DR GenomeRNAi; 401665; -.
DR Pharos; Q8NGJ9; Tdark.
DR PRO; PR:Q8NGJ9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ9; protein.
DR Bgee; ENSG00000176900; Expressed in prostate gland.
DR ExpressionAtlas; Q8NGJ9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Olfactory receptor 51T1"
FT /id="PRO_0000150763"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 327 AA; 36998 MW; 357B024140657D44 CRC64;
MAIFNNTTSS SSNFLLTAFP GLECAHVWIS IPVCCLYTIA LLGNSMIFLV IITKRRLHKP
MYYFLSMLAA VDLCLTITTL PTVLGVLWFH AREISFKACF IQMFFVHAFS LLESSVLVAM
AFDRFVAICN PLNYATILTD RMVLVIGLVI CIRPAVFLLP LLVAINTVSF HGGHELSHPF
CYHPEVIKYT YSKPWISSFW GLFLQLYLNG TDVLFILFSY VLILRTVLGI VARKKQQKAL
STCVCHICAV TIFYVPLISL SLAHRLFHST PRVLCSTLAN IYLLLPPVLN PIIYSLKTKT
IRQAMFQLLQ SKGSWGFNVR GLRGRWD
