O51V1_HUMAN
ID O51V1_HUMAN Reviewed; 321 AA.
AC Q9H2C8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 51V1;
DE AltName: Full=Odorant receptor HOR3'beta1;
DE AltName: Full=Olfactory receptor 51A12;
DE AltName: Full=Olfactory receptor OR11-36;
GN Name=OR51V1; Synonyms=OR51A12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [5]
RP VARIANT VAL-211.
RX PubMed=26282398; DOI=10.1186/s13023-015-0316-8;
RA Dahmani M., Ammar-Khodja F., Bonnet C., Lefevre G.M., Hardelin J.P.,
RA Ibrahim H., Mallek Z., Petit C.;
RT "EPS8L2 is a new causal gene for childhood onset autosomal recessive
RT progressive hearing loss.";
RL Orphanet J. Rare Dis. 10:96-96(2015).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51V1";
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DR EMBL; AF289203; AAG42364.1; -; Genomic_DNA.
DR EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004432; DAA04830.1; -; Genomic_DNA.
DR RefSeq; NP_001004760.2; NM_001004760.2.
DR AlphaFoldDB; Q9H2C8; -.
DR SMR; Q9H2C8; -.
DR BioGRID; 129462; 2.
DR STRING; 9606.ENSP00000321729; -.
DR GlyGen; Q9H2C8; 1 site.
DR iPTMnet; Q9H2C8; -.
DR PhosphoSitePlus; Q9H2C8; -.
DR BioMuta; OR51V1; -.
DR DMDM; 296439246; -.
DR PaxDb; Q9H2C8; -.
DR PeptideAtlas; Q9H2C8; -.
DR PRIDE; Q9H2C8; -.
DR DNASU; 283111; -.
DR GeneID; 283111; -.
DR KEGG; hsa:283111; -.
DR UCSC; uc010qyz.2; human.
DR CTD; 283111; -.
DR DisGeNET; 283111; -.
DR GeneCards; OR51V1; -.
DR HGNC; HGNC:19597; OR51V1.
DR neXtProt; NX_Q9H2C8; -.
DR PharmGKB; PA134873075; -.
DR eggNOG; ENOG502SHMK; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H2C8; -.
DR OrthoDB; 872597at2759; -.
DR PhylomeDB; Q9H2C8; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H2C8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9H2C8; -.
DR BioGRID-ORCS; 283111; 13 hits in 643 CRISPR screens.
DR GeneWiki; OR51V1; -.
DR GenomeRNAi; 283111; -.
DR Pharos; Q9H2C8; Tdark.
DR PRO; PR:Q9H2C8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H2C8; protein.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 51V1"
FT /id="PRO_0000150764"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 211
FT /note="L -> V"
FT /evidence="ECO:0000269|PubMed:26282398"
FT /id="VAR_079498"
FT VARIANT 233
FT /note="S -> L (in dbSNP:rs7933549)"
FT /id="VAR_057580"
FT CONFLICT 36
FT /note="L -> F (in Ref. 1; AAG42364)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="G -> R (in Ref. 1; AAG42364)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 36749 MW; 3CF758D12EB5B1A0 CRC64;
MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG NCMVLHVIWT
EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE ISLDSCIAQS YFIHGLSFME
SSVLLTMAFD RYIAICNPLR YSSILTNSRI IKIGLTIIGR SFFFITPPII CLKFFNYCHF
HILSHSFCLH QDLLRLACSD IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ
EERHKLFQTC ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII
YSVKTQQIHT RMLRLFSLKR Y
