O52A1_HUMAN
ID O52A1_HUMAN Reviewed; 312 AA.
AC Q9UKL2; Q6IF31;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Olfactory receptor 52A1;
DE AltName: Full=HPFH1OR;
DE AltName: Full=Odorant receptor HOR3'beta4;
DE AltName: Full=Olfactory receptor OR11-319;
GN Name=OR52A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10512676; DOI=10.1006/geno.1999.5935;
RA Feingold E.A., Penny L.A., Nienhuis A.W., Forget B.G.;
RT "An olfactory receptor gene is located in the extended human beta-globin
RT gene cluster and is expressed in erythroid cells.";
RL Genomics 61:15-23(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52A1";
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DR EMBL; AF154673; AAD51279.1; -; Genomic_DNA.
DR EMBL; AF289204; AAG42367.1; -; Genomic_DNA.
DR EMBL; AC129505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111722; AAI11723.1; -; mRNA.
DR EMBL; BK004431; DAA04829.1; -; Genomic_DNA.
DR CCDS; CCDS31374.1; -.
DR RefSeq; NP_036507.2; NM_012375.2.
DR AlphaFoldDB; Q9UKL2; -.
DR SMR; Q9UKL2; -.
DR STRING; 9606.ENSP00000369725; -.
DR GlyGen; Q9UKL2; 1 site.
DR BioMuta; OR52A1; -.
DR DMDM; 296439247; -.
DR PaxDb; Q9UKL2; -.
DR PeptideAtlas; Q9UKL2; -.
DR PRIDE; Q9UKL2; -.
DR Antibodypedia; 55354; 110 antibodies from 21 providers.
DR DNASU; 23538; -.
DR Ensembl; ENST00000380367.3; ENSP00000369725.1; ENSG00000182070.7.
DR GeneID; 23538; -.
DR KEGG; hsa:23538; -.
DR MANE-Select; ENST00000380367.3; ENSP00000369725.1; NM_012375.3; NP_036507.2.
DR UCSC; uc010qyy.2; human.
DR CTD; 23538; -.
DR GeneCards; OR52A1; -.
DR HGNC; HGNC:8318; OR52A1.
DR HPA; ENSG00000182070; Not detected.
DR neXtProt; NX_Q9UKL2; -.
DR OpenTargets; ENSG00000182070; -.
DR PharmGKB; PA32392; -.
DR VEuPathDB; HostDB:ENSG00000182070; -.
DR eggNOG; ENOG502SITM; Eukaryota.
DR GeneTree; ENSGT01050000244967; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9UKL2; -.
DR OMA; CRFQLYH; -.
DR OrthoDB; 912949at2759; -.
DR PhylomeDB; Q9UKL2; -.
DR TreeFam; TF352744; -.
DR PathwayCommons; Q9UKL2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 23538; 6 hits in 675 CRISPR screens.
DR GeneWiki; OR52A1; -.
DR GenomeRNAi; 23538; -.
DR Pharos; Q9UKL2; Tdark.
DR PRO; PR:Q9UKL2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9UKL2; protein.
DR Bgee; ENSG00000182070; Expressed in upper leg skin.
DR Genevisible; Q9UKL2; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR GO; GO:0007608; P:sensory perception of smell; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 52A1"
FT /id="PRO_0000150765"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 272
FT /note="S -> P (in Ref. 1; AAD51279, 2; AAG42367 and 4;
FT AAI11723)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35322 MW; B05AFD46352D513C CRC64;
MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI IKSERSLHEP
LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL LQMWFIHTLQ GIESGILVAM
ALDRYVAICY PLRHANIFTH QLVIQIGTMV VLRAAILVAP CLVLIKCRFQ FYHTTVISHS
YCEHMAIVKL AAANVQVNKI YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA
FNTCIAHICV FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT
QIRIHVVKMF CS
