O52A4_HUMAN
ID O52A4_HUMAN Reviewed; 304 AA.
AC A6NMU1; B9EIN7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Olfactory receptor 52A4;
GN Name=OR52A4P {ECO:0000312|HGNC:HGNC:19579}; Synonyms=OR52A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-180; ARG-277 AND
RP ALA-303.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52A4";
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DR EMBL; AC113331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140752; AAI40753.1; -; mRNA.
DR AlphaFoldDB; A6NMU1; -.
DR SMR; A6NMU1; -.
DR GlyGen; A6NMU1; 1 site.
DR BioMuta; HGNC:19579; -.
DR PeptideAtlas; A6NMU1; -.
DR PRIDE; A6NMU1; -.
DR GeneCards; OR52A4P; -.
DR HGNC; HGNC:19579; OR52A4P.
DR neXtProt; NX_A6NMU1; -.
DR InParanoid; A6NMU1; -.
DR PhylomeDB; A6NMU1; -.
DR PathwayCommons; A6NMU1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; A6NMU1; Tdark.
DR PRO; PR:A6NMU1; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NMU1; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..304
FT /note="Olfactory receptor 52A4"
FT /id="PRO_0000312527"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 87
FT /note="D -> G (in dbSNP:rs7947334)"
FT /id="VAR_037540"
FT VARIANT 180
FT /note="Y -> S (in dbSNP:rs10837375)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037541"
FT VARIANT 277
FT /note="C -> R (in dbSNP:rs4426129)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037542"
FT VARIANT 303
FT /note="T -> A (in dbSNP:rs10837374)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062081"
SQ SEQUENCE 304 AA; 34901 MW; A8D18FB656D95552 CRC64;
MALPITNGTL FMPFVLTFIG IPGFESVQCW IGIPFCATYV IALIGNSLLL IIIKSEPSLH
EPMYIFLATL GATDISLSTS IVPKMLDIFW FHLPEIYFDA CLFQMWLIHT FQGIESGVLL
AMALDRCVAI CYPLRRAIVF TRQLVTYIVV GVTLRPAILV IPCLLLIKCH LKLYRTKLIY
HTYCERVALV KLATEDVYIN KVYGILGAFI VGGLDFIFIT LSYIQIFITV FHLPLKEARL
KVFNTCIPHI YVFFQFYLLA FFFIFYSQIW ILYPIICTYH LVQSLPTGPT IPQPLYLWVK
DQTH
