ID   O52A5_HUMAN             Reviewed;         316 AA.
AC   Q9H2C5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Olfactory receptor 52A5;
DE   AltName: Full=Odorant receptor HOR3'beta5;
DE   AltName: Full=Olfactory receptor OR11-33;
GN   Name=OR52A5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA   Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA   Felsenfeld G., Groudine M., Hardison R.;
RT   "Comparative structural and functional analysis of the olfactory receptor
RT   genes flanking the human and mouse beta-globin gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52A5";
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DR   EMBL; AF289204; AAG42368.1; -; Genomic_DNA.
DR   EMBL; BK004433; DAA04831.1; -; Genomic_DNA.
DR   CCDS; CCDS31373.1; -.
DR   RefSeq; NP_001005160.1; NM_001005160.2.
DR   AlphaFoldDB; Q9H2C5; -.
DR   SMR; Q9H2C5; -.
DR   STRING; 9606.ENSP00000303469; -.
DR   GlyGen; Q9H2C5; 1 site.
DR   BioMuta; OR52A5; -.
DR   DMDM; 74762730; -.
DR   PaxDb; Q9H2C5; -.
DR   PeptideAtlas; Q9H2C5; -.
DR   PRIDE; Q9H2C5; -.
DR   ProteomicsDB; 80528; -.
DR   Antibodypedia; 23571; 117 antibodies from 19 providers.
DR   DNASU; 390054; -.
DR   Ensembl; ENST00000307388.2; ENSP00000303469.1; ENSG00000171944.2.
DR   Ensembl; ENST00000642125.1; ENSP00000493298.1; ENSG00000171944.2.
DR   GeneID; 390054; -.
DR   KEGG; hsa:390054; -.
DR   MANE-Select; ENST00000307388.2; ENSP00000303469.1; NM_001005160.3; NP_001005160.1.
DR   UCSC; uc010qyx.2; human.
DR   CTD; 390054; -.
DR   GeneCards; OR52A5; -.
DR   HGNC; HGNC:19580; OR52A5.
DR   HPA; ENSG00000171944; Not detected.
DR   neXtProt; NX_Q9H2C5; -.
DR   PharmGKB; PA134991603; -.
DR   VEuPathDB; HostDB:ENSG00000171944; -.
DR   eggNOG; ENOG502SITM; Eukaryota.
DR   GeneTree; ENSGT01050000244967; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9H2C5; -.
DR   OMA; HMPQISF; -.
DR   OrthoDB; 889142at2759; -.
DR   PhylomeDB; Q9H2C5; -.
DR   TreeFam; TF352744; -.
DR   PathwayCommons; Q9H2C5; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q9H2C5; -.
DR   BioGRID-ORCS; 390054; 6 hits in 672 CRISPR screens.
DR   GeneWiki; OR52A5; -.
DR   GenomeRNAi; 390054; -.
DR   Pharos; Q9H2C5; Tdark.
DR   PRO; PR:Q9H2C5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H2C5; protein.
DR   Bgee; ENSG00000171944; Expressed in gonad and 2 other tissues.
DR   ExpressionAtlas; Q9H2C5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 52A5"
FT                   /id="PRO_0000150766"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  35955 MW;  0B0820B4BE747623 CRC64;
     MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI IKYENSLHIP
     MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL FQMWLIHSFQ AIESGILLAM
     ALDRYVAICI PLRHATIFSQ QFLTHIGLGV TLRAAILIIP SLGLIKCCLK HYRTTVISHS
     YCEHMAIVKL ATEDIRVNKI YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA
     FNTCIAHICV FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK
     QIRDHIVKVF FFKKVT