O52B2_HUMAN
ID O52B2_HUMAN Reviewed; 323 AA.
AC Q96RD2; Q8NGM7;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 3.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Olfactory receptor 52B2;
DE AltName: Full=Olfactory receptor OR11-70;
GN Name=OR52B2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-287.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52B2";
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DR EMBL; AB065763; BAC05983.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68744.1; -; Genomic_DNA.
DR EMBL; BC136732; AAI36733.1; -; mRNA.
DR EMBL; BC136733; AAI36734.1; -; mRNA.
DR EMBL; AF399505; AAK94990.1; -; Genomic_DNA.
DR EMBL; BK004324; DAA04722.1; -; Genomic_DNA.
DR CCDS; CCDS53598.1; -.
DR RefSeq; NP_001004052.1; NM_001004052.1.
DR AlphaFoldDB; Q96RD2; -.
DR SMR; Q96RD2; -.
DR BioGRID; 129115; 20.
DR STRING; 9606.ENSP00000432011; -.
DR GlyGen; Q96RD2; 1 site.
DR iPTMnet; Q96RD2; -.
DR PhosphoSitePlus; Q96RD2; -.
DR BioMuta; OR52B2; -.
DR DMDM; 221222519; -.
DR PaxDb; Q96RD2; -.
DR PeptideAtlas; Q96RD2; -.
DR PRIDE; Q96RD2; -.
DR Antibodypedia; 57973; 68 antibodies from 19 providers.
DR DNASU; 255725; -.
DR Ensembl; ENST00000530810.2; ENSP00000432011.1; ENSG00000255307.2.
DR GeneID; 255725; -.
DR KEGG; hsa:255725; -.
DR MANE-Select; ENST00000530810.2; ENSP00000432011.1; NM_001004052.1; NP_001004052.1.
DR UCSC; uc010qzy.3; human.
DR CTD; 255725; -.
DR GeneCards; OR52B2; -.
DR HGNC; HGNC:15207; OR52B2.
DR HPA; ENSG00000255307; Not detected.
DR neXtProt; NX_Q96RD2; -.
DR PharmGKB; PA32396; -.
DR VEuPathDB; HostDB:ENSG00000255307; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01000000214548; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q96RD2; -.
DR OMA; FVHVMFV; -.
DR OrthoDB; 1013884at2759; -.
DR PhylomeDB; Q96RD2; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q96RD2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 255725; 12 hits in 669 CRISPR screens.
DR GeneWiki; OR52B2; -.
DR GenomeRNAi; 255725; -.
DR Pharos; Q96RD2; Tdark.
DR PRO; PR:Q96RD2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96RD2; protein.
DR Bgee; ENSG00000255307; Expressed in ganglionic eminence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 52B2"
FT /id="PRO_0000150767"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 105
FT /note="F -> Y (in dbSNP:rs16909422)"
FT /id="VAR_054126"
SQ SEQUENCE 323 AA; 36185 MW; D7C9A5138AB6AB17 CRC64;
MSHTNVTIFH PAVFVLPGIP GLEAYHIWLS IPLCLIYITA VLGNSILIVV IVMERNLHVP
MYFFLSMLAV MDILLSTTTV PKALAIFWLQ AHNIAFDACV TQGFFVHMMF VGESAILLAM
AFDRFVAICA PLRYTTVLTW PVVGRIALAV ITRSFCIIFP VIFLLKRLPF CLTNIVPHSY
CEHIGVARLA CADITVNIWY GFSVPIVMVI LDVILIAVSY SLILRAVFRL PSQDARHKAL
STCGSHLCVI LMFYVPSFFT LLTHHFGRNI PQHVHILLAN LYVAVPPMLN PIVYGVKTKQ
IREGVAHRFF DIKTWCCTSP LGS
