O52B4_HUMAN
ID O52B4_HUMAN Reviewed; 314 AA.
AC Q8NGK2; A6NP68; Q6IFK6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 52B4;
DE AltName: Full=Olfactory receptor OR11-3;
GN Name=OR52B4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [6]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon at position Ala-40 in the gene coding for
CC this protein is responsible for functional diversity thus producing a
CC pseudogene. The stop codon is more frequent in non-Africans than in
CC African-Americans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52B4";
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DR EMBL; AB065792; BAC06011.1; -; Genomic_DNA.
DR EMBL; AC009758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68847.1; -; Genomic_DNA.
DR EMBL; BK004256; DAA04654.1; -; Genomic_DNA.
DR RefSeq; NP_001005161.2; NM_001005161.3.
DR AlphaFoldDB; Q8NGK2; -.
DR SMR; Q8NGK2; -.
DR STRING; 9606.ENSP00000485078; -.
DR GlyGen; Q8NGK2; 1 site.
DR iPTMnet; Q8NGK2; -.
DR PhosphoSitePlus; Q8NGK2; -.
DR BioMuta; OR52B4; -.
DR DMDM; 68600998; -.
DR PaxDb; Q8NGK2; -.
DR PeptideAtlas; Q8NGK2; -.
DR PRIDE; Q8NGK2; -.
DR Antibodypedia; 78461; 2 antibodies from 2 providers.
DR DNASU; 143496; -.
DR Ensembl; ENST00000624801.3; ENSP00000485530.1; ENSG00000221996.6.
DR GeneID; 143496; -.
DR KEGG; hsa:143496; -.
DR MANE-Select; ENST00000624801.3; ENSP00000485530.1; NM_001005161.3; NP_001005161.2.
DR UCSC; uc010qye.2; human.
DR CTD; 143496; -.
DR DisGeNET; 143496; -.
DR GeneCards; OR52B4; -.
DR HGNC; HGNC:15209; OR52B4.
DR HPA; ENSG00000221996; Not detected.
DR neXtProt; NX_Q8NGK2; -.
DR PharmGKB; PA32398; -.
DR VEuPathDB; HostDB:ENSG00000221996; -.
DR eggNOG; ENOG502RTZX; Eukaryota.
DR GeneTree; ENSGT01000000214548; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGK2; -.
DR OMA; FHMPSPD; -.
DR OrthoDB; 900491at2759; -.
DR PhylomeDB; Q8NGK2; -.
DR TreeFam; TF352745; -.
DR PathwayCommons; Q8NGK2; -.
DR BioGRID-ORCS; 143496; 8 hits in 662 CRISPR screens.
DR GeneWiki; OR52B4; -.
DR GenomeRNAi; 143496; -.
DR Pharos; Q8NGK2; Tdark.
DR PRO; PR:Q8NGK2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK2; protein.
DR ExpressionAtlas; Q8NGK2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0050890; P:cognition; IMP:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 52B4"
FT /id="PRO_0000150768"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 139
FT /note="T -> I (in dbSNP:rs11031961)"
FT /id="VAR_037834"
SQ SEQUENCE 314 AA; 35584 MW; 001831EAE8314474 CRC64;
MPTVNHSGTS HTVFHLLGIP GLQDQHMWIS IPFFISYVTA LLGNSLLIFI ILTKRSLHEP
MYLFLCMLAG ADIVLSTCTI PQALAIFWFR AGDISLDRCI TQLFFIHSTF ISESGILLVM
AFDHYIAICY PLRYTTILTN ALIKKICVTV SLRSYGTIFP IIFLLKRLTF CQNNIIPHTF
CEHIGLAKYA CNDIRINIWY GFSILMSTVV LDVVLIFISY MLILHAVFHM PSPDACHKAL
NTFGSHVCII ILFYGSGIFT ILTQRFGRHI PPCIHIPLAN VCILAPPMLN PIIYGIKTKQ
IQEQVVQFLF IKQK
