O52B6_HUMAN
ID O52B6_HUMAN Reviewed; 335 AA.
AC Q8NGF0; Q6IFI7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 52B6;
DE AltName: Full=Olfactory receptor OR11-47;
GN Name=OR52B6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-22 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52B6";
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DR EMBL; AB065858; BAC06076.1; -; Genomic_DNA.
DR EMBL; AC015691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004275; DAA04673.1; -; Genomic_DNA.
DR CCDS; CCDS41611.1; -.
DR RefSeq; NP_001005162.2; NM_001005162.2.
DR AlphaFoldDB; Q8NGF0; -.
DR SMR; Q8NGF0; -.
DR STRING; 9606.ENSP00000341581; -.
DR GlyGen; Q8NGF0; 1 site.
DR iPTMnet; Q8NGF0; -.
DR PhosphoSitePlus; Q8NGF0; -.
DR BioMuta; OR52B6; -.
DR DMDM; 218512128; -.
DR PaxDb; Q8NGF0; -.
DR PeptideAtlas; Q8NGF0; -.
DR PRIDE; Q8NGF0; -.
DR Antibodypedia; 70926; 28 antibodies from 14 providers.
DR DNASU; 340980; -.
DR Ensembl; ENST00000345043.2; ENSP00000341581.2; ENSG00000187747.2.
DR GeneID; 340980; -.
DR KEGG; hsa:340980; -.
DR MANE-Select; ENST00000345043.2; ENSP00000341581.2; NM_001005162.2; NP_001005162.2.
DR UCSC; uc010qzi.2; human.
DR CTD; 340980; -.
DR GeneCards; OR52B6; -.
DR HGNC; HGNC:15211; OR52B6.
DR HPA; ENSG00000187747; Not detected.
DR neXtProt; NX_Q8NGF0; -.
DR PharmGKB; PA32400; -.
DR VEuPathDB; HostDB:ENSG00000187747; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01000000214548; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGF0; -.
DR OMA; FIIMFPS; -.
DR OrthoDB; 919170at2759; -.
DR PhylomeDB; Q8NGF0; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGF0; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 340980; 6 hits in 671 CRISPR screens.
DR GeneWiki; OR52B6; -.
DR GenomeRNAi; 340980; -.
DR Pharos; Q8NGF0; Tdark.
DR PRO; PR:Q8NGF0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF0; protein.
DR Bgee; ENSG00000187747; Expressed in sural nerve and 6 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..335
FT /note="Olfactory receptor 52B6"
FT /id="PRO_0000150769"
FT TOPO_DOM 1..45
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..293
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 117..208
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 57
FT /note="T -> A (in dbSNP:rs1077126)"
FT /id="VAR_048077"
FT VARIANT 111
FT /note="L -> H (in dbSNP:rs2341432)"
FT /id="VAR_048078"
FT VARIANT 167
FT /note="A -> T (in dbSNP:rs2341433)"
FT /id="VAR_048079"
FT VARIANT 170
FT /note="H -> R (in dbSNP:rs2341434)"
FT /id="VAR_048080"
FT VARIANT 288
FT /note="V -> I (in dbSNP:rs10769086)"
FT /id="VAR_048081"
SQ SEQUENCE 335 AA; 36963 MW; F1F3458611158252 CRC64;
MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP FCIMYITALE
GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK ALANLWLGYS LISFDGCLTQ
MFFIHFLFIH SAVLLAMAFD RYVAICSPLR YVTILTSKVI GKIVTAALSH SFIIMFPSIF
LLEHLHYCQI NIIAHTFCEH MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI
LQAVFRLLSQ DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY
VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK
