O52D1_HUMAN
ID O52D1_HUMAN Reviewed; 318 AA.
AC Q9H346; B9EGY9; Q6IFI6;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Olfactory receptor 52D1;
DE AltName: Full=Odorant receptor HOR5'beta14;
DE AltName: Full=Olfactory receptor OR11-43;
GN Name=OR52D1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52D1";
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DR EMBL; AF137396; AAG41676.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68791.1; -; Genomic_DNA.
DR EMBL; BC136928; AAI36929.1; -; mRNA.
DR EMBL; BC136930; AAI36931.1; -; mRNA.
DR EMBL; BK004276; DAA04674.1; -; Genomic_DNA.
DR CCDS; CCDS31384.1; -.
DR RefSeq; NP_001005163.1; NM_001005163.2.
DR AlphaFoldDB; Q9H346; -.
DR SMR; Q9H346; -.
DR STRING; 9606.ENSP00000326232; -.
DR GlyGen; Q9H346; 1 site.
DR iPTMnet; Q9H346; -.
DR PhosphoSitePlus; Q9H346; -.
DR BioMuta; OR52D1; -.
DR DMDM; 14423837; -.
DR PaxDb; Q9H346; -.
DR PRIDE; Q9H346; -.
DR Antibodypedia; 55470; 123 antibodies from 24 providers.
DR DNASU; 390066; -.
DR Ensembl; ENST00000322641.5; ENSP00000326232.5; ENSG00000181609.5.
DR GeneID; 390066; -.
DR KEGG; hsa:390066; -.
DR MANE-Select; ENST00000322641.5; ENSP00000326232.5; NM_001005163.2; NP_001005163.1.
DR UCSC; uc010qzg.3; human.
DR CTD; 390066; -.
DR GeneCards; OR52D1; -.
DR HGNC; HGNC:15212; OR52D1.
DR HPA; ENSG00000181609; Tissue enhanced (testis).
DR neXtProt; NX_Q9H346; -.
DR PharmGKB; PA32401; -.
DR VEuPathDB; HostDB:ENSG00000181609; -.
DR eggNOG; ENOG502SHDP; Eukaryota.
DR GeneTree; ENSGT01000000214548; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H346; -.
DR OMA; FGHHEVP; -.
DR OrthoDB; 992043at2759; -.
DR PhylomeDB; Q9H346; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q9H346; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390066; 10 hits in 679 CRISPR screens.
DR GeneWiki; OR52D1; -.
DR GenomeRNAi; 390066; -.
DR Pharos; Q9H346; Tdark.
DR PRO; PR:Q9H346; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H346; protein.
DR Bgee; ENSG00000181609; Expressed in sural nerve and 4 other tissues.
DR ExpressionAtlas; Q9H346; baseline and differential.
DR Genevisible; Q9H346; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 52D1"
FT /id="PRO_0000150770"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 154
FT /note="R -> C (in dbSNP:rs7935144)"
FT /id="VAR_034331"
FT VARIANT 213
FT /note="D -> E (in dbSNP:rs7924754)"
FT /id="VAR_034332"
FT VARIANT 221
FT /note="Y -> F (in dbSNP:rs7950082)"
FT /id="VAR_034333"
FT VARIANT 251
FT /note="I -> T (in dbSNP:rs7101919)"
FT /id="VAR_024146"
FT VARIANT 304
FT /note="R -> W (in dbSNP:rs11037758)"
FT /id="VAR_034334"
SQ SEQUENCE 318 AA; 35122 MW; 178968087D613CB2 CRC64;
MSDSNLSDNH LPDTFFLTGI PGLEAAHFWI AIPFCAMYLV ALVGNAALIL VIAMDNALHA
PMYLFLCLLS LTDLALSSTT VPKMLAILWL HAGEISFGGC LAQMFCVHSI YALESSILLA
MAFDRYVAIC NPLRYTTILN HAVIGRIGFV GLFRSVAIVS PFIFLLRRLP YCGHRVMTHT
YCEHMGIARL ACANITVNIV YGLTVALLAM GLDSILIAIS YGFILHAVFH LPSHDAQHKA
LSTCGSHIGI ILVFYIPAFF SFLTHRFGHH EVPKHVHIFL ANLYVLVPPV LNPILYGART
KEIRSRLLKL LHLGKTSI
