ID   O52E1_HUMAN             Reviewed;         308 AA.
AC   Q8NGJ3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Olfactory receptor 52E1;
GN   Name=OR52E1; Synonyms=OR52E1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E1P";
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DR   EMBL; AB065801; BAC06020.1; -; Genomic_DNA.
DR   CCDS; CCDS86173.1; -.
DR   RefSeq; NP_001335150.1; NM_001348221.1.
DR   AlphaFoldDB; Q8NGJ3; -.
DR   SMR; Q8NGJ3; -.
DR   GlyGen; Q8NGJ3; 1 site.
DR   BioMuta; HGNC:14766; -.
DR   DMDM; 38372705; -.
DR   PeptideAtlas; Q8NGJ3; -.
DR   PRIDE; Q8NGJ3; -.
DR   DNASU; 79296; -.
DR   GeneID; 79296; -.
DR   KEGG; hsa:79296; -.
DR   CTD; 79296; -.
DR   GeneCards; OR52E1; -.
DR   HGNC; HGNC:14766; OR52E1.
DR   neXtProt; NX_Q8NGJ3; -.
DR   PharmGKB; PA32402; -.
DR   InParanoid; Q8NGJ3; -.
DR   OrthoDB; 927322at2759; -.
DR   PhylomeDB; Q8NGJ3; -.
DR   PathwayCommons; Q8NGJ3; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 79296; 0 hits in 31 CRISPR screens.
DR   Pharos; Q8NGJ3; Tdark.
DR   PRO; PR:Q8NGJ3; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8NGJ3; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Olfactory receptor 52E1"
FT                   /id="PRO_0000150771"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..53
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   308 AA;  34714 MW;  5B59F836BF3EFA88 CRC64;
     MNTTLFHPYS FLLLGIPGLE SMHLWVGFPF FAVFLTAVLG NITILFVIQT DSSLHHPMFY
     FLAILSSIDP GLSTSTIPKM LGTFWFTLRE ISFEGCLTQM FFIHLCTGME SAVLVAMAYD
     CYVAICDPLC YTLVLTNKVV SVMALAIFLR PLVFVIPFVL FILRLPFCGH QIIPHTYGEH
     MGIARLSCAS IRVNIIYGLC AISILVFDII AIVISYVQIL CAVFLLSSHD ARLKAFSTCG
     SHVCVMLTFY MPAFFSFMTH RFGRNIPHFI HILLANFYVV IPPALNSVIY GVRTKQIRAQ
     VLKMFFNK