O52E2_HUMAN
ID O52E2_HUMAN Reviewed; 325 AA.
AC Q8NGJ4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 52E2;
GN Name=OR52E2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-264.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E2";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065800; BAC06019.1; -; Genomic_DNA.
DR EMBL; AC113331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31371.1; -.
DR RefSeq; NP_001005164.2; NM_001005164.2.
DR AlphaFoldDB; Q8NGJ4; -.
DR SMR; Q8NGJ4; -.
DR STRING; 9606.ENSP00000322088; -.
DR GlyGen; Q8NGJ4; 1 site.
DR PhosphoSitePlus; Q8NGJ4; -.
DR BioMuta; OR52E2; -.
DR DMDM; 296439248; -.
DR PaxDb; Q8NGJ4; -.
DR PeptideAtlas; Q8NGJ4; -.
DR PRIDE; Q8NGJ4; -.
DR Antibodypedia; 49353; 124 antibodies from 25 providers.
DR DNASU; 119678; -.
DR Ensembl; ENST00000321522.2; ENSP00000322088.2; ENSG00000176787.2.
DR GeneID; 119678; -.
DR KEGG; hsa:119678; -.
DR MANE-Select; ENST00000321522.2; ENSP00000322088.2; NM_001005164.2; NP_001005164.2.
DR UCSC; uc010qyw.2; human.
DR CTD; 119678; -.
DR DisGeNET; 119678; -.
DR GeneCards; OR52E2; -.
DR HGNC; HGNC:14769; OR52E2.
DR HPA; ENSG00000176787; Not detected.
DR neXtProt; NX_Q8NGJ4; -.
DR PharmGKB; PA32403; -.
DR VEuPathDB; HostDB:ENSG00000176787; -.
DR eggNOG; ENOG502RNPB; Eukaryota.
DR GeneTree; ENSGT01050000244945; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ4; -.
DR OMA; VRAFIFV; -.
DR OrthoDB; 834914at2759; -.
DR PhylomeDB; Q8NGJ4; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGJ4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGJ4; -.
DR BioGRID-ORCS; 119678; 11 hits in 672 CRISPR screens.
DR GeneWiki; OR52E2; -.
DR GenomeRNAi; 119678; -.
DR Pharos; Q8NGJ4; Tdark.
DR PRO; PR:Q8NGJ4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 52E2"
FT /id="PRO_0000150772"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 5
FT /note="N -> S (in dbSNP:rs16909440)"
FT /id="VAR_053332"
FT VARIANT 167
FT /note="R -> W (in dbSNP:rs11035396)"
FT /id="VAR_053333"
FT VARIANT 264
FT /note="R -> C (in dbSNP:rs2500052)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_053334"
SQ SEQUENCE 325 AA; 36630 MW; 96F7CD13A53148BA CRC64;
MFLPNDTQFH PSSFLLLGIP GLETLHIWIG FPFCAVYMIA LIGNFTILLV IKTDSSLHQP
MFYFLAMLAT TDVGLSTATI PKMLGIFWIN LRGIIFEACL TQMFFIHNFT LMESAVLVAM
AYDSYVAICN PLQYSAILTN KVVSVIGLGV FVRALIFVIP SILLILRLPF CGNHVIPHTY
CEHMGLAHLS CASIKINIIY GLCAICNLVF DITVIALSYV HILCAVFRLP THEARLKSLS
TCGSHVCVIL AFYTPALFSF MTHRFGRNVP RYIHILLANL YVVVPPMLNP VIYGVRTKQI
YKCVKKILLQ EQGMEKEEYL IHTRF
